Identification of 3-(benzazol-2-yl)quinoxaline derivatives as potent anticancer compounds: Privileged structure-based design, synthesis, and bioactive evaluation in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.004
Abstract: Inspired by the common structural characteristics of numerous known antitumor compounds targeting DNA or topoisomerase I, 3-(benzazol-2-yl)-quinoxaline-based scaffold was designed via the combination of two important privileged structure units -quinoxaline and benzazole. Thirty novel 3-(benzazol-2-yl)-quinoxaline… read more here.
Keywords: benzazol quinoxaline; quinoxaline derivatives; chemistry; privileged structure ... See more keywords
Recent advances of quinones as a privileged structure in drug discovery.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113632
Abstract: Privileged structures are conductive to discover novel bioactive substances because they can bind to multiple targets with high affinity. Quinones are considered to be a privileged structure and useful template for the design of new… read more here.
Keywords: advances quinones; quinones privileged; privileged structure; recent advances ... See more keywords
Chalcone: A Privileged Structure in Medicinal Chemistry.
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DOI: 10.1021/acs.chemrev.7b00020
Abstract: Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared… read more here.
Keywords: privileged structure; medicinal chemistry; chemistry; chalcone privileged ... See more keywords
Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46272-y
Abstract: Bisphenol A (BPA) is used as an industrial raw material for polycarbonate plastics and epoxy resins; however, various concerns have been reported regarding its status as an endocrine-disrupting chemical. BPA interacts not only with oestrogen… read more here.
Keywords: bisphenol; privileged structure; novel oestrogen; discovery novel ... See more keywords