Privileged Structures and Polypharmacology within and between Protein Families
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DOI: 10.1021/acsmedchemlett.8b00364
Abstract: Polypharmacology is often a key contributor to the efficacy of a drug, but is also a potential risk. We investigated two hits discovered via a cell-based phenotypic screen, the CDK9 inhibitor CCT250006 (1) and the… read more here.
Keywords: protein families; privileged structures; polypharmacology; polypharmacology within ... See more keywords