Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.111117
Abstract: PDE8B, PRKAR1A and the Wnt/β-catenin signaling are involved in endocrine disorders. However, how PDEB8B interacts with both Wnt and protein kinase A (PKA) signaling in vivo remains unknown. We created a novel Pde8b knockout mouse… read more here.
Keywords: pde8b; wnt; prkar1a; steroidogenesis ... See more keywords
P06.04 Enhancing T cell function for cancer immunotherapy by microRNA mediated knockdown of PRKAR1A
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-itoc7.83
Abstract: Background Protein Kinase A (PKA) is a heterotetramer holoenzyme that consists of two regulatory and catalytic subunits. During T cell activation, one of the regulatory subunits (PRKAR1A) localizes to the immune synapse, inhibiting several central… read more here.
Keywords: cell function; prkar1a; cancer; cell ... See more keywords
Somatic PRKAR1A mutation in sporadic atrial myxoma with cerebral parenchymal metastases: a case report
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Case Reports"
DOI: 10.1186/s13256-019-2317-z
Abstract: BackgroundAtrial myxomas are generally considered benign neoplasms. The majority of tumors are sporadic and less than 10% are associated with an autosomal dominant condition known as the Carney complex, which is most often caused by… read more here.
Keywords: prkar1a; case; atrial myxoma; mutation ... See more keywords