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   Articles with "prkn" as a keyword



Parkin is Transcriptionally Regulated by the Aryl Hydrocarbon Receptor: Impact on α-Synuclein Protein Levels.

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recommendations! Published in 2019 at "Biochemical pharmacology"

DOI: 10.1016/j.bcp.2019.08.002

Abstract: Parkin (PRKN) is a ubiquitin E3 ligase that catalyzes the ubiquitination of several proteins. Mutations in the human Parkin gene, PRKN, leads to degeneration of dopaminergic (DA) neurons, resulting in autosomal recessive early-onset parkinsonism and… read more here.

Keywords: aryl hydrocarbon; hydrocarbon receptor; prkn; protein levels ... See more keywords
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PTEN-L puts a brake on mitophagy

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recommendations! Published in 2018 at "Autophagy"

DOI: 10.1080/15548627.2018.1502565

Abstract: ABSTRACT Mitophagy is a main type of selective autophagy, via which damaged mitochondria are selectively degraded via the autophagic pathway. The protein kinase PINK1 and E3 ubiquitin ligase PRKN are the most well studied regulators… read more here.

Keywords: protein; pten puts; brake mitophagy; prkn ... See more keywords
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Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy

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recommendations! Published in 2019 at "Autophagy"

DOI: 10.1080/15548627.2019.1596494

Abstract: ABSTRACT Mitochondrial dynamics is highly implicated in a plethora of cellular processes including apoptosis and mitophagy. However, little is known about the scope and precise functions of mitochondrial dynamics proteins for mitochondrial quality control and… read more here.

Keywords: protein; mief1 mid51; prkn; mief1 ... See more keywords
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HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner

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recommendations! Published in 2020 at "Autophagy"

DOI: 10.1080/15548627.2020.1725401

Abstract: ABSTRACT Macroautophagy/autophagy is an auto-digestive pro-survival pathway activated in response to stress to target cargo for lysosomal degradation. In recent years, autophagy has become prominent as an innate antiviral defense mechanism through multiple processes, such… read more here.

Keywords: restriction; hiv; enhancing association; prkn ... See more keywords
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Regulation of PRKN-Independent Mitophagy.

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recommendations! Published in 2021 at "Autophagy"

DOI: 10.1080/15548627.2021.1888244

Abstract: Mitochondria are dynamic, multifunctional cellular organelles that play a fundamental role in maintaining cellular homeostasis. Keeping the quality of mitochondria in check is of essential importance for functioning and survival of the cells. Selective autophagic… read more here.

Keywords: regulation prkn; independent mitophagy; prkn independent; prkn ... See more keywords
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Feedforward activation of PRKN/parkin

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2100615

Abstract: ABSTRACT Parkinson disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the midbrain. The majority of early onset forms of Parkinson disease are a result of autosomal mutations in PRKN… read more here.

Keywords: activation prkn; parkinson disease; feedforward activation; prkn ... See more keywords
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Novel Compound Heterozygous PRKN Variants in a Han-Chinese Family with Early-Onset Parkinson's Disease

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recommendations! Published in 2019 at "Parkinson's Disease"

DOI: 10.1155/2019/9024894

Abstract: Genetic factors are thought to play an important role in the pathogenesis of Parkinson's disease (PD), particularly early-onset PD. The PRKN gene is the primary disease-causing gene for early-onset PD. The details of its functions… read more here.

Keywords: early onset; disease; novel compound; prkn ... See more keywords
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Large Intronic Deletion of the Fragile Site Gene PRKN Dramatically Lowers Its Fragility Without Impacting Gene Expression

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recommendations! Published in 2021 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2021.695172

Abstract: Common chromosomal fragile sites (CFSs) are genomic regions prone to form breaks and gaps on metaphase chromosomes during conditions of replication stress. Moreover, CFSs are hotspots for deletions and amplifications in cancer genomes. Fragility at… read more here.

Keywords: fragility; expression; prkn; intronic deletion ... See more keywords
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Frequency of Heterozygous Parkin (PRKN) Variants and Penetrance of Parkinson's Disease Risk Markers in the Population-Based CHRIS Cohort

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recommendations! Published in 2021 at "Frontiers in Neurology"

DOI: 10.3389/fneur.2021.706145

Abstract: Mutations in the Parkin (PRKN) gene are the most frequent cause of autosomal recessive early-onset Parkinson's disease (PD). Heterozygous PRKN mutation carriers might also be at increased risk for developing clinical symptoms of PD. Given… read more here.

Keywords: risk; mutation carriers; parkin prkn; prkn ... See more keywords