SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1643185
Abstract: ABSTRACT The ubiquitination of mitochondrial proteins labels damaged mitochondria for degradation through mitophagy. We recently developed an in vivo system in which mitophagy is slowed by inhibiting mitochondrial division through knockout of Dnm1l/Drp1, a dynamin… read more here.
Keywords: pink1 prkn; prkn parkin; mitochondrial ubiquitination; mitophagy ... See more keywords
Endosomal-associated RFFL facilitates mitochondrial clearance by enhancing PRKN/parkin recruitment to mitochondria.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2052460
Abstract: Mutations in the ubiquitin ligase PRKN (parkin RBR E3 ubiquitin protein ligase) are associated with Parkinson disease and defective mitophagy. Conceptually, PRKN-dependent mitophagy is classified into two phases: 1. PRKN recruits to and ubiquitinates mitochondrial… read more here.
Keywords: ubiquitin protein; prkn parkin; protein ligase; rffl ... See more keywords
Feedforward activation of PRKN/parkin
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DOI: 10.1080/15548627.2022.2100615
Abstract: ABSTRACT Parkinson disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the midbrain. The majority of early onset forms of Parkinson disease are a result of autosomal mutations in PRKN… read more here.
Keywords: activation prkn; parkinson disease; feedforward activation; prkn ... See more keywords