Immunohistochemical localization of prolactin receptor (PRLR) to Hodgkin's and Reed-Sternberg cells of Hodgkin's lymphoma.
Sign Up to like & getrecommendations! Published in 2020 at "Acta histochemica"
DOI: 10.1016/j.acthis.2020.151657
Abstract: Prolactin receptor (PRLR), a type-1 cytokine receptor, is overexpressed in a number of cancer types. It has attracted much attention for putative pro-oncogenic roles, which however, remains controversial in some malignancies. In this study, we… read more here.
Keywords: prlr hodgkin; prlr; prolactin receptor; receptor prlr ... See more keywords
Molecular Evolutionary Insights from PRLR in Mammals.
Sign Up to like & getrecommendations! Published in 2021 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2021.113791
Abstract: Prolactin (PRL) is a pleiotropic neurohormone secreted by the mammalian pituitary gland into the blood, thus reaching many tissues and organs beyond the brain. PRL binds to its receptor, PRLR, eliciting a molecular signaling cascade.… read more here.
Keywords: molecular evolutionary; prlr; evolutionary insights; prlr mammals ... See more keywords
Prolactin and prolactin receptor expression in the HPG axis and crop during parental care in both sexes of a biparental bird (Columba livia).
Sign Up to like & getrecommendations! Published in 2021 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2021.113940
Abstract: During breeding, multiple circulating hormones, including prolactin, facilitate reproductive transitions in species that exhibit parental care. Prolactin underlies parental behaviors and related physiological changes across many vertebrates, including birds and mammals. While circulating prolactin levels… read more here.
Keywords: parental care; prlr; prolactin; expression ... See more keywords
Prolactin Acts on Myeloid Progenitors to Modulate SMAD7 Expression and Enhance Hematopoietic Stem Cell Differentiation into the NK Cell Lineage
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DOI: 10.1038/s41598-020-63346-4
Abstract: Numerous cell types modulate hematopoiesis through soluble and membrane bound molecules. Whether developing hematopoietic progenitors of a particular lineage modulate the differentiation of other hematopoietic lineages is largely unknown. Here we aimed to investigate the… read more here.
Keywords: myeloid progenitors; prlr; cell differentiation; lineage ... See more keywords
Association of prolactin receptor (PRLR) variants with prolactinomas
Sign Up to like & getrecommendations! Published in 2019 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy396
Abstract: Abstract Prolactinomas are the most frequent type of pituitary tumors, which represent 10–20% of all intracranial neoplasms in humans. Prolactinomas develop in mice lacking the prolactin receptor (PRLR), which is a member of the cytokine… read more here.
Keywords: receptor prlr; prlr; prolactin receptor; prlr variants ... See more keywords
Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12908
Abstract: In addition to its critical role in lactation, the anterior pituitary hormone prolactin also influences a broad range of other physiological processes. In particular, widespread expression of prolactin receptor (Prlr) in the brain has highlighted… read more here.
Keywords: prlr; prolactin receptor; prolactin; expressing neurones ... See more keywords
PRL/PRLR Can Promote Insulin Resistance by Activating the JAK2/STAT5 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/1456187
Abstract: Objective Although prolactin (PRL) is known to affect food intake, weight gain, and insulin resistance, its effects on lipid metabolism and underlying mechanisms remain underinvestigated. This study aimed to investigate the effects of PRL and… read more here.
Keywords: prlr; insulin resistance; stat5; group ... See more keywords
Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-19-1026
Abstract: Abnormal activity of human prolactin (PRL) and its membrane-associated receptor (PRLR) contributes to the progression of uterine carcinoma. However, the underlying mechanisms are not well understood, and current means of targeting the PRL/PRLR axis in… read more here.
Keywords: prlr; cell death; eif 4ebp1; foxo3a eif ... See more keywords
Identification of prolactin receptor variants with diverse effects on receptor signalling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Endocrinology"
DOI: 10.1530/jme-22-0164
Abstract: The prolactin receptor (PRLR) signals predominantly through the JAK2-STAT5 pathway regulating multiple physiological functions relating to fertility, lactation, and metabolism. However, the molecular pathology and role of PRLR mutations and signalling are incompletely defined, with… read more here.
Keywords: prlr; prolactin receptor; prlr variants; receptor ... See more keywords
Prolactin receptor gene transcriptional control, regulatory modalities relevant to breast cancer resistance and invasiveness
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.949396
Abstract: The prolactin receptor (PRLR) is a member of the lactogen/cytokine receptor family, which mediates multiple actions of prolactin (PRL). PRL is a major hormone in the proliferation/differentiation of breast epithelium that is essential for lactation.… read more here.
Keywords: prlr; breast cancer; prl; receptor ... See more keywords
Prolactin Inducible Protein, but Not Prolactin, Is Present in Human Tears, Is Involved in Tear Film Quality, and Influences Evaporative Dry Eye Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.892831
Abstract: Purpose Decreased production of the aqueous component of the tear film is an important cause of the development of dry eye disease (DED). Tear production is influenced by hormones and hormone-like factors. Prolactin (PLR), a… read more here.
Keywords: pip; quality; prlr; prlr pip ... See more keywords