Feasibility of function-guided lung treatment planning with parametric response mapping.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of applied clinical medical physics"
DOI: 10.1002/acm2.13436
Abstract: PURPOSE Recent advancements in functional lung imaging have been developed to improve clinicians' knowledge of patient pulmonary condition prior to treatment. Ultimately, it may be possible to employ these functional imaging modalities to tailor radiation… read more here.
Keywords: treatment planning; treatment; lung; prm ... See more keywords
Immuno-Engineered Nanodecoys for the Multi-Target Anti-Inflammatory Treatment of Autoimmune Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced materials"
DOI: 10.1002/adma.202108817
Abstract: Over-activated T cells and over-produced pro-inflammatory cytokines form a self-amplified signaling loop to continuously exacerbate the dysregulated inflammatory response and propel the progression of autoimmune diseases (AIDs). Herein, immuno-engineered nanodecoys (NDs) based on poly(lactic-co-glycolic acid)… read more here.
Keywords: prm; engineered nanodecoys; autoimmune diseases; immuno engineered ... See more keywords
High-Resolution Parallel Reaction Monitoring with Electron Transfer Dissociation for Middle-Down Proteomics: An Application to Study the Quantitative Changes Induced by Histone Modifying Enzyme Inhibitors and Activators.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7201-2_4
Abstract: With the advent of new methodologies, proteomics-based assays are increasingly used to study the efficacy of drugs on a molecular level. For these studies to be meaningful, the proteomics assays need to be sensitive, selective,… read more here.
Keywords: parallel reaction; modifying enzyme; reaction monitoring; prm ... See more keywords
Ubiquitination of Zika Virus Precursor Membrane Protein Promotes the Release of Viral Proteins.
Sign Up to like & getrecommendations! Published in 2020 at "Virus research"
DOI: 10.1016/j.virusres.2020.198065
Abstract: Zika virus (ZIKV) is an important human pathogen associated with severe neurological disorders. Ubiquitination of viral proteins has diverse roles in viral life cycle and pathogenesis. Here, we found that perturbation of ubiquitin-proteasome system significantly… read more here.
Keywords: protein; prm; precursor membrane; viral proteins ... See more keywords
The Parallel Reaction Monitoring-Parallel Accumulation-Serial Fragmentation (prm-PASEF) Approach for Multiplexed Absolute Quantitation of Proteins in Human Plasma.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c03782
Abstract: Mass spectrometry (MS)-based quantitative proteomic methods have become some of the major tools for protein biomarker discovery and validation. The recently developed parallel reaction monitoring-parallel accumulation-serial fragmentation (prm-PASEF) approach on a Bruker timsTOF Pro mass… read more here.
Keywords: prm; prm pasef; pasef approach; human plasma ... See more keywords
A Pradimicin-Based Staining Dye for Glycoprotein Detection.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c00506
Abstract: Pradimicin A (PRM-A) and related compounds constitute an exceptional family of natural pigments that show Ca2+-dependent recognition of d-mannose (Man). Although these compounds hold great promise as research tools in glycobiology, their practical application has… read more here.
Keywords: dye glycoprotein; detection; pradimicin based; prm ... See more keywords
Efficacy of a T Cell-Biased Adenovirus Vector as a Zika Virus Vaccine
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35755-z
Abstract: Zika virus (ZIKV) is a major public health concern due to the risk of congenital Zika syndrome in developing fetuses and Guillain-Barre syndrome in adults. Currently, there are no approved vaccines available to protect against… read more here.
Keywords: vaccine; zikv; prm; ad4 prm ... See more keywords
Chimeric viruses between Rocio and West Nile: the role for Rocio prM-E proteins in virulence and inhibition of interferon-α/β signaling
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44642
Abstract: Mosquito-transmitted flavivirus Rocio (ROCV) was responsible for an outbreak of encephalitis in the Ribeira Valley, located in the south coast of Sao Paulo State, Brazil, in 1975–1976. ROCV also causes fatal encephalitis in adult mice.… read more here.
Keywords: rocv; rocio; prm proteins; prm ... See more keywords
prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2218899120
Abstract: Cleavage of the flavivirus premembrane (prM) structural protein during maturation can be inefficient. The contribution of partially mature flavivirus virions that retain uncleaved prM to pathogenesis during primary infection is unknown. To investigate this question,… read more here.
Keywords: prm; partially mature; prm reactive; pathogenesis ... See more keywords
Premature Aircraft Maintenance: A Matter of Cost or Risk?
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Transactions on Systems, Man, and Cybernetics: Systems"
DOI: 10.1109/tsmc.2019.2895207
Abstract: Despite recent advances in aircraft maintenance technology, the breakdowns and catastrophic accidents due to human failure during maintenance activities will continue to occur. This paper argues that the impact of human error is amplified by… read more here.
Keywords: methodology; premature aircraft; aircraft maintenance; maintenance ... See more keywords
Zika Virus NS2A-Mediated Virion Assembly
Sign Up to like & getrecommendations! Published in 2019 at "mBio"
DOI: 10.1128/mbio.02375-19
Abstract: ZIKV is a recently emerged mosquito-borne flavivirus that can cause devastating congenital Zika syndrome in pregnant women and Guillain-Barré syndrome in adults. The molecular mechanism of ZIKV virion assembly is largely unknown. Here, we report… read more here.
Keywords: zikv; virion; virion assembly; viral rna ... See more keywords