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   Articles with "prmt1" as a keyword



PRMT1‐mediated arginine methylation promotes YAP activation and hepatocellular carcinoma proliferation

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recommendations! Published in 2024 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13909

Abstract: The activity of Hippo signaling is commonly dysregulated in various human malignancies, including hepatocellular carcinoma (HCC). YAP, the key effector of Hippo pathway, is regulated through several posttranslational modifications. However, the mechanism by which YAP… read more here.

Keywords: arginine methylation; methylation; prmt1; hcc ... See more keywords

Modulation of I Ks channel–PIP2 interaction by PRMT1 plays a critical role in the control of cardiac repolarization

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recommendations! Published in 2022 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.30775

Abstract: Recent studies have shown that protein arginine methyltransferase 1 (PRMT1) is highly expressed in the human heart, and loss of PRMT1 contributes to cardiac remodeling in the heart failure. However, the functional importance of PRMT1… read more here.

Keywords: furamidine; pip2 interaction; prmt1; channel pip2 ... See more keywords

TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.

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recommendations! Published in 2017 at "Cell reports"

DOI: 10.1016/j.celrep.2017.11.007

Abstract: Apoptosis signal-regulating kinase 1 (ASK1) is an oxidative stress-responsive kinase that is regulated by various interacting molecules and post-translational modifications. However, how these molecules and modifications cooperatively regulate ASK1 activity remains largely unknown. Here, we… read more here.

Keywords: prmt1; cell death; activation; ask1 activation ... See more keywords

CSNK1a1 Regulates PRMT1 to Maintain the Progenitor State in Self-Renewing Somatic Tissue.

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recommendations! Published in 2017 at "Developmental cell"

DOI: 10.1016/j.devcel.2017.08.021

Abstract: Somatic progenitors sustain tissue self-renewal while suppressing premature differentiation. Protein arginine methyltransferases (PRMTs) affect many processes; however, their role in progenitor function is incompletely understood. PRMT1 was found to be the most highly expressed PRMT… read more here.

Keywords: csnk1a1; premature differentiation; tissue; prmt1 ... See more keywords

Prmt1 regulates craniofacial bone formation upstream of Msx1

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recommendations! Published in 2018 at "Mechanisms of Development"

DOI: 10.1016/j.mod.2018.05.001

Abstract: Protein arginine methylation has been recently identified as an important form of post-translational modification (PTM). It is carried out by the protein arginine methyltransferase (PRMT) family of enzymes, which in mammals consists of nine members.… read more here.

Keywords: msx1; craniofacial bone; formation; prmt1 ... See more keywords

The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex

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recommendations! Published in 2017 at "Nature Immunology"

DOI: 10.1038/ni.3774

Abstract: Developing pre-B cells in the bone marrow alternate between proliferation and differentiation phases. We found that protein arginine methyl transferase 1 (PRMT1) and B cell translocation gene 2 (BTG2) are critical components of the pre-B… read more here.

Keywords: btg2 prmt1; pre cell; prmt1; cell ... See more keywords

Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-07606-y

Abstract: Dysregulation of Ca2+/calmodulin-dependent protein kinase (CaMK)II is closely linked with myocardial hypertrophy and heart failure. However, the mechanisms that regulate CaMKII activity are incompletely understood. Here we show that protein arginine methyltransferase 1 (PRMT1) is essential… read more here.

Keywords: heart; dysregulation; heart failure; prmt1 ... See more keywords

Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking

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recommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1804091115

Abstract: Significance Endocytosis plays a fundamental role in Wnt signaling, leading to the sequestration of cytosolic GSK3 kinase inside multivesicular endosomes. Here we show an unexpected role for the enzyme protein arginine methyltransferase 1 (PRMT1) during… read more here.

Keywords: wnt signaling; wnt; canonical wnt; arginine methylation ... See more keywords

PRMT1 driven PTX3 regulates ferritinophagy in glioma.

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recommendations! Published in 2023 at "Autophagy"

DOI: 10.1080/15548627.2023.2165757

Abstract: Mutations in the Krebs cycle enzyme IDH1 (isocitrate dehydrogenase (NADP(+)) 1) are associated with better prognosis in gliomas. Though IDH1 mutant (IDH1R132H) tumors are characterized by their antiproliferative signatures maintained through hypermethylation of DNA and… read more here.

Keywords: idh1 mutant; idh1; ptx3; prmt1 ... See more keywords

Ligand‐independent EphA2 contributes to chemoresistance in small‐cell lung cancer by enhancing PRMT1‐mediated SOX2 methylation

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recommendations! Published in 2022 at "Cancer Science"

DOI: 10.1111/cas.15653

Abstract: Chemoresistance is the crux of clinical treatment failure of small‐cell lung cancer (SCLC). Cancer stem cells play a critical role in therapeutic resistance of malignant tumors. Studies have shown that the role of erythropoietin‐producing hepatocellular… read more here.

Keywords: ligand independent; small cell; prmt1; epha2 ... See more keywords

Oxidative stress state inhibits exosome secretion of hPDLCs through a specific mechanism mediated by PRMT1.

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recommendations! Published in 2022 at "Journal of periodontal research"

DOI: 10.1111/jre.13040

Abstract: BACKGROUND AND OBJECTIVES Periodontitis, the most common chronic inflammation characterized by persistent alveolar bone resorption in the periodontitis, affects almost half of the adult population worldwide. Oxidative stress is one of the pathophysiological mechanisms underlying… read more here.

Keywords: hpdlcs; exosome secretion; oxidative stress; prmt1 ... See more keywords