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Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30775
Abstract: Recent studies have shown that protein arginine methyltransferase 1 (PRMT1) is highly expressed in the human heart, and loss of PRMT1 contributes to cardiac remodeling in the heart failure. However, the functional importance of PRMT1…
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Keywords:
furamidine;
pip2 interaction;
prmt1;
channel pip2 ... See more keywords
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1
Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.11.007
Abstract: Apoptosis signal-regulating kinase 1 (ASK1) is an oxidative stress-responsive kinase that is regulated by various interacting molecules and post-translational modifications. However, how these molecules and modifications cooperatively regulate ASK1 activity remains largely unknown. Here, we…
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Keywords:
prmt1;
cell death;
activation;
ask1 activation ... See more keywords
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1
Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.08.021
Abstract: Somatic progenitors sustain tissue self-renewal while suppressing premature differentiation. Protein arginine methyltransferases (PRMTs) affect many processes; however, their role in progenitor function is incompletely understood. PRMT1 was found to be the most highly expressed PRMT…
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Keywords:
csnk1a1;
premature differentiation;
tissue;
prmt1 ... See more keywords
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Published in 2018 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2018.05.001
Abstract: Protein arginine methylation has been recently identified as an important form of post-translational modification (PTM). It is carried out by the protein arginine methyltransferase (PRMT) family of enzymes, which in mammals consists of nine members.…
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Keywords:
msx1;
craniofacial bone;
formation;
prmt1 ... See more keywords
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Published in 2017 at "Nature Immunology"
DOI: 10.1038/ni.3774
Abstract: Developing pre-B cells in the bone marrow alternate between proliferation and differentiation phases. We found that protein arginine methyl transferase 1 (PRMT1) and B cell translocation gene 2 (BTG2) are critical components of the pre-B…
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Keywords:
btg2 prmt1;
pre cell;
prmt1;
cell ... See more keywords
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Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07606-y
Abstract: Dysregulation of Ca2+/calmodulin-dependent protein kinase (CaMK)II is closely linked with myocardial hypertrophy and heart failure. However, the mechanisms that regulate CaMKII activity are incompletely understood. Here we show that protein arginine methyltransferase 1 (PRMT1) is essential…
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Keywords:
heart;
dysregulation;
heart failure;
prmt1 ... See more keywords
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Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1804091115
Abstract: Significance Endocytosis plays a fundamental role in Wnt signaling, leading to the sequestration of cytosolic GSK3 kinase inside multivesicular endosomes. Here we show an unexpected role for the enzyme protein arginine methyltransferase 1 (PRMT1) during…
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Keywords:
wnt signaling;
wnt;
canonical wnt;
arginine methylation ... See more keywords
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2
Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2165757
Abstract: Mutations in the Krebs cycle enzyme IDH1 (isocitrate dehydrogenase (NADP(+)) 1) are associated with better prognosis in gliomas. Though IDH1 mutant (IDH1R132H) tumors are characterized by their antiproliferative signatures maintained through hypermethylation of DNA and…
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Keywords:
idh1 mutant;
idh1;
ptx3;
prmt1 ... See more keywords
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1
Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15653
Abstract: Chemoresistance is the crux of clinical treatment failure of small‐cell lung cancer (SCLC). Cancer stem cells play a critical role in therapeutic resistance of malignant tumors. Studies have shown that the role of erythropoietin‐producing hepatocellular…
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Keywords:
ligand independent;
small cell;
prmt1;
epha2 ... See more keywords
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1
Published in 2022 at "Journal of periodontal research"
DOI: 10.1111/jre.13040
Abstract: BACKGROUND AND OBJECTIVES Periodontitis, the most common chronic inflammation characterized by persistent alveolar bone resorption in the periodontitis, affects almost half of the adult population worldwide. Oxidative stress is one of the pathophysiological mechanisms underlying…
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Keywords:
hpdlcs;
exosome secretion;
oxidative stress;
prmt1 ... See more keywords
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2
Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abm6265
Abstract: Inflammatory cytokine–induced activation of nuclear factor κB (NF-κB) signaling plays a critical role in the pathogenesis of osteoarthritis (OA). We identified PILA as a long noncoding RNA (lncRNA) that enhances NF-κB signaling and OA. The…
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Keywords:
cartilage;
factor;
prmt1;
pila ... See more keywords