Cisplatin-induced ototoxicity involves interaction of PRMT3 and cannabinoid system
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DOI: 10.1007/s00204-019-02507-5
Abstract: This study investigated whether protein arginine methyltransferase (PRMT) and the cannabinoid system are involved in cisplatin-induced ototoxicity. Cisplatin increased cytosine–cytosine–adenosine–adenosine–thymidine–enhancer-binding protein homologous protein expression. This effect is indicative of an increase in endoplasmic reticulum (ER)… read more here.
Keywords: cisplatin; induced ototoxicity; cannabinoid; cisplatin induced ... See more keywords
Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.7b01674
Abstract: PRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins. It is crucial for maturation of ribosomes and has been implicated in several diseases. We recently disclosed a highly potent, selective, and cell-active allosteric… read more here.
Keywords: potent selective; discovery potent; allosteric inhibitors; selective allosteric ... See more keywords
Ribosomal Protein uS5 and Friends: Protein–Protein Interactions Involved in Ribosome Assembly and Beyond
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DOI: 10.3390/biom13050853
Abstract: Ribosomal proteins are fundamental components of the ribosomes in all living cells. The ribosomal protein uS5 (Rps2) is a stable component of the small ribosomal subunit within all three domains of life. In addition to… read more here.
Keywords: prmt3; protein us5; ribosomal protein; us5 friends ... See more keywords
Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression
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DOI: 10.3390/cancers11010008
Abstract: Pancreatic cancer is poorly responsive to chemotherapy due to intrinsic or acquired resistance. Our previous study showed that epigenetic modifying enzymes including protein arginine methyltransferase 3 (PRMT3) are dysregulated in gemcitabine (GEM)-resistant pancreatic cancer cells.… read more here.
Keywords: pancreatic cancer; protein arginine; expression; abcg2 ... See more keywords