TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24883
Abstract: Protein arginine methyltransferase (PRMT) 4 (also known as coactivator-associated arginine methyltransferase 1; CARM1) is involved in a variety of biological processes and is considered as a candidate oncogene owing to its overexpression in several types… read more here.
Keywords: potent selective; 064 potent; selective small; multiple myeloma ... See more keywords
PRMT4 facilitates white adipose tissue browning and thermogenesis by methylating PPARĪ³.
Sign Up to like & getrecommendations! Published in 2023 at "Diabetes"
DOI: 10.2337/db22-1016
Abstract: Obesity is a global health threat, and the induction of white adipose tissue (WAT) browning presents a promising therapeutic method for it. Recent publications revealed the essential role of protein arginine methyltransferase 4 (PRMT4) in… read more here.
Keywords: wat browning; adipose tissue; white adipose; prmt4 ... See more keywords