Development of Macrocyclic PRMT5–Adaptor Protein Interaction Inhibitors
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DOI: 10.1021/acs.jmedchem.2c01273
Abstract: The PRMT5-MEP50 methyltransferase is a major target for anticancer drug discovery, and modulators of its interactions with different regulatory proteins are in high demand because they modulate PRMT5 substrate selectivity. We describe a strategy for… read more here.
Keywords: prmt5 adaptor; interaction; adaptor protein; adaptor ... See more keywords