PRMT7 deficiency enhances adipogenesis through modulation of C/EBP-β.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.07.096
Abstract: Obesity that is critically correlated with the initiation and development of metabolic syndrome and cardiovascular diseases has increased worldwide. Adipogenesis is coordinated through multi-steps involving adipogenic commitment, mitotic clonal expansion (MCE) and differentiation. Recently, protein… read more here.
Keywords: adipogenesis; adipogenesis modulation; modulation ebp; prmt7 ... See more keywords
Development of Novel PRMT7 Inhibitors for the Treatment of Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c02978
Abstract: Prostate cancer (PCa) remains a prevalent malignancy in men and warrants novel and efficacious therapy. Protein arginine methyltransferase 7 (PRMT7) has been recently identified as a promising target for PCa treatment, however, the development of… read more here.
Keywords: prostate cancer; pca; prmt7 inhibitors; prmt7 ... See more keywords
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28809-4
Abstract: Extravasation of monocytes into tissue and to the site of injury is a fundamental immunological process, which requires rapid responses via post translational modifications (PTM) of proteins. Protein arginine methyltransferase 7 (PRMT7) is an epigenetic… read more here.
Keywords: injury; arginine methyltransferase; extravasation monocytes; methyltransferase prmt7 ... See more keywords
Prmt7 regulates epiboly and gastrulation cell movements by facilitating syntenin
Sign Up to like & getrecommendations! Published in 2018 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.1093/abbs/gmy136
Abstract: Epiboly spreads and thins the blastoderm over the yolk cell during zebrafish gastrulation. Despite of its fundamental function, little is known about the molecular mechanisms that control this coordinated cell movement. In this study, we… read more here.
Keywords: facilitating syntenin; prmt7; cell movements; cell ... See more keywords
PRMT7 modulates neuronal excitability by interacting with NaV1.9.
Sign Up to like & getrecommendations! Published in 2021 at "Pain"
DOI: 10.1097/j.pain.0000000000002421
Abstract: ABSTRACT Human NaV1.9 (hNaV1.9), encoded by SCN11A, is preferentially expressed in nociceptors, and its mutations have been linked to pain disorders. NaV1.9 could be a promising drug target for pain relief. However, the modulation of… read more here.
Keywords: neuronal excitability; scn11a mice; prmt7 modulates; prmt7 ... See more keywords
Targeting PRMT7 enhances the anti-AML immunity by regulating MHC-I
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-387
Abstract: Protein arginine methylation regulates several cellular functions, including RNA splicing, translation and DNA damage repair. Protein arginine N-methyltransferase (PRMT) dysregulation is often seen in malignant hematopoiesis. PRMT7, the only type III PRMT, catalyzes monomethyl arginine… read more here.
Keywords: cd8 cells; aml; mhc; cell ... See more keywords
PRMT7 Inhibitor SGC3027 Enhances Radiotherapy Efficacy via Activating ATM Kinase in Non-Small Cell Lung Carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Radiation Research"
DOI: 10.1667/rade-24-00242.1
Abstract: Non-small-cell lung cancer (NSCLC) is the leading cause of tumor-related death in humans. Radiotherapy is a crucial strategy for NSCLC treatment, although its effectiveness is limited by the radio-resistance of tumor cells. Our current research… read more here.
Keywords: non small; sgc3027; cell lung; small cell ... See more keywords
PRMT7 contributes to the metastasis phenotype in human non-small-cell lung cancer cells possibly through the interaction with HSPA5 and EEF2
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s166412
Abstract: Background Non-small-cell lung cancer (NSCLC) constitutes the leading cause of cancer death in humans. Previous studies revealed the essential role of the protein arginine methyltransferase 7 (PRMT7) in promoting metastasis in breast cancer. However, its… read more here.
Keywords: hspa5 eef2; prmt7; lung cancer; cancer ... See more keywords
PRMT7 Inhibitor SGC8158 Enhances Doxorubicin-Induced DNA Damage and Its Cytotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012323
Abstract: Protein arginine methyltransferase 7 (PRMT7) regulates various cellular responses, including gene expression, cell migration, stress responses, and stemness. In this study, we investigated the biological role of PRMT7 in cell cycle progression and DNA damage… read more here.
Keywords: cell; dna; dna damage; prmt7 ... See more keywords