An unusual familial dementia associated with G131V PRNP mutation
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Neurology"
DOI: 10.1111/ene.14559
Abstract: Gerstmann‐Struassler‐Scheinker disease is one of the familial prion diseases secondary to mutations in the prion protein gene (PRNP). The clinical phenotype has a diverse spectrum and might show variation among cases with the same genotype.… read more here.
Keywords: prnp; dementia associated; unusual familial; familial dementia ... See more keywords
Downregulated PRNP Facilitates Cell Proliferation and Invasion and Has Effect on the Immune Regulation in Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/3205040
Abstract: Background Ovarian cancer (OC) seriously threatens women's life. Ferroptosis plays an essential role in the initiation and development of OC. However, more molecular targets and mechanisms for ferroptosis in OC remain to be further elucidated.… read more here.
Keywords: gene; ovarian cancer; expression; ferroptosis ... See more keywords
Transmissible spongiform encephalopathy in goats: is PrP rapid test sensitivity affected by genotype?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Veterinary Diagnostic Investigation"
DOI: 10.1177/1040638719896327
Abstract: Transmissible spongiform encephalopathy (TSE) surveillance in goats relies on tests initially approved for cattle, subsequently assessed for sheep, and approval extrapolated for use in “small ruminants.” The current EU-approved immunodetection tests employ antibodies against various… read more here.
Keywords: transmissible spongiform; prnp; test sensitivity; spongiform encephalopathy ... See more keywords
Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary Research"
DOI: 10.1186/s13567-021-00993-z
Abstract: To date, chronic wasting disease (CWD) is the most infectious form of prion disease affecting several captive, free ranging and wild cervid species. Responsible for marked population declines in North America, its geographical spread is… read more here.
Keywords: prnp; cwd; wasting disease; genetics ... See more keywords
Clinicopathological features of the rare form of Creutzfeldt-Jakob disease in R208H-V129V PRNP carrier
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-019-0699-1
Abstract: To the Editor, Genetic transmissible spongiform encephalopathy (TSE) diseases are always associated with one of the more than 50 disease-associated point or insert mutations of the PrP gene (PRNP) [12] and represent approximately 10 to… read more here.
Keywords: prnp; r208h; disease; jakob disease ... See more keywords
High-Depth PRNP Sequencing in Brains With Sporadic Creutzfeldt-Jakob Disease
Sign Up to like & getrecommendations! Published in 2023 at "Neurology: Genetics"
DOI: 10.1212/nxg.0000000000200054
Abstract: Background and Objectives Sporadic Creutzfeldt-Jakob disease (sCJD) has established genetic risk factors, but, in contrast to genetic and acquired CJD, the initial trigger for misfolded prion aggregation and spread is not known. In this study,… read more here.
Keywords: disease; creutzfeldt jakob; scjd; sporadic creutzfeldt ... See more keywords
Analysis of experimental mouse PRNP genetic polymorphisms and their susceptibility to prion diseases
Sign Up to like & getrecommendations! Published in 2017 at "Indian Journal of Animal Research"
DOI: 10.18805/ijar.v0iof.9183
Abstract: Research studies showed that the polymorphisms in prion protein gene (PRNP) were associated with susceptibility to prion diseases in several animals, including humans and mouse. Several mouse strains carried natural PRNP mutations which had been… read more here.
Keywords: susceptibility prion; prnp; prion; prion diseases ... See more keywords