Effect of UV Stress on the Structure and Function of Pro‐apoptotic Bid and Anti‐apoptotic Bcl‐xl proteins
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200682
Abstract: Ultraviolet C (UV‐C) radiation induces apoptosis in mammalian cells via the mitochondrion‐mediated pathway. The Bcl‐2 family of proteins are the regulators of the mitochondrial pathway of apoptosis and appears responsive to UV‐C radiation. It is… read more here.
Keywords: pro apoptotic; structure function; function pro; bid ... See more keywords
The Pro-Apoptotic Activity of Tamarixetin on Liver Cancer Cells Via Regulation Mitochondrial Apoptotic Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-019-03033-x
Abstract: Based on the various pharmacological activities of tamarixetin, the present study investigated the cytotoxicity property of tamarixetin in human liver cancer cells including PLC/PRF/5 and HepG2 cells, and their xenografted tumor nude mice. In cells,… read more here.
Keywords: tamarixetin; liver cancer; pro apoptotic; cancer cells ... See more keywords
Novel thiazolidine derivatives as potent selective pro-apoptotic agents.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105143
Abstract: A series of 2-arylthiazolidine-4-carboxylic acid amide derivatives were synthesized and their cytotoxic activity against three cancer cell lines (PC-3, SKOV3 and MDA-MB231) was evaluated. Various structural modifications were tried including modifications of the length of… read more here.
Keywords: pro apoptotic; expression; cancer cells; cancer ... See more keywords
Hollongdione arylidene derivatives induce antiproliferative activity against melanoma and breast cancer through pro-apoptotic and antiangiogenic mechanisms.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105535
Abstract: The use of natural compounds as starting point for semisynthetic derivatives has already been proven as a valuable source of active anticancer agents. Hollongdione (4,4,8,14-tetramethyl-18-norpregnan-3,20-dion), obtained by few steps from dammarane type triterpenoid dipterocarpol, was… read more here.
Keywords: cancer; apoptotic antiangiogenic; antiproliferative activity; activity ... See more keywords
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114274
Abstract: Autophagy is a lysosome dependent cell survival mechanism and is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Targeting autophagy in cancer therapy attracted considerable attention in the past as… read more here.
Keywords: cancer; microtubule targeting; targeting agents; cell ... See more keywords
Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.05.029
Abstract: BAX is a pro-apoptotic protein that transforms from a cytosolic monomer into a toxic oligomer that permeabilizes the mitochondrial outer membrane. How BAX monomers assemble into a higher-order conformation, and the structural determinants essential to… read more here.
Keywords: bax; pro apoptotic; membrane permeabilization; membrane ... See more keywords
Altered expression of genes involved in programmed cell death in primary cultured rat cerebellar granule cells acutely challenged with tetrabromobisphenol A
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.09.014
Abstract: HighlightsThe viability of primary CGC continuously declines after acute challenge with TBBPA.Genes related to programmed necrosis are not induced in CGC by TBBPA.Early suppression by TBBPA of the autophagy and apoptotic genes in CGC.Delayed activation… read more here.
Keywords: genes involved; mgr tbbpa; expression genes; pro apoptotic ... See more keywords
Pro-apoptotic activity of acylated triterpenoid saponins from the stem bark of Albizia chevalieri harms
Sign Up to like & getrecommendations! Published in 2017 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2017.09.008
Abstract: Abstract As a continuation of our interest in apoptosis-inducing triterpenoid saponins from Albizia genus, phytochemical investigation of the stem bark of Albizia chevalieri led to the isolation of three new oleanane-type saponins, named chevalierosides A–C… read more here.
Keywords: triterpenoid saponins; pro apoptotic; stem bark; bark albizia ... See more keywords
Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association.
Sign Up to like & getrecommendations! Published in 2020 at "Structure"
DOI: 10.1016/j.str.2020.09.002
Abstract: Bcl-2 proteins orchestrate the mitochondrial pathway of apoptosis, pivotal for cell death. Yet, the structural details of the conformational changes of pro- and antiapoptotic proteins and their interactions remain unclear. Pulse dipolar spectroscopy (double electron-electron… read more here.
Keywords: bimbh3; apoptotic bimbh3; pro apoptotic; characterization pro ... See more keywords
Biological Hyperthermia-Inducing Nanoparticles for Specific Remodeling of the Extracellular Matrix Microenvironment Enhance Pro-Apoptotic Therapy in Fibrosis.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c12831
Abstract: The extracellular matrix (ECM) is a major driver of fibrotic diseases and forms a dense fibrous barrier that impedes nanodrug delivery. Because hyperthermia causes destruction of ECM components, we developed a nanoparticle preparation to induce… read more here.
Keywords: pro apoptotic; dnp; biological hyperthermia; fibrosis ... See more keywords
Pro-apoptotic liposomes-nanobubble conjugate synergistic with paclitaxel: a platform for ultrasound responsive image-guided drug delivery
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21084-8
Abstract: Recently, liposomes-microbubble conjugates have emerged as a promising ultrasound (US)-responsive platform for cancer therapeutics. However, these are limited by their size in terms of tumor penetration. Additionally, there have been no attempts to enhance the… read more here.
Keywords: liposomes nanobubble; pro apoptotic; ultrasound responsive; responsive image ... See more keywords