PCSK9 promotes arterial medial calcification.
Sign Up to like & getrecommendations! Published in 2022 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2022.01.015
Abstract: BACKGROUND AND AIMS A complex interplay among chronic kidney disease (CKD), lipid metabolism and aortic calcification has been recognized. Here we investigated the influence of kidney function on PCSK9 levels and its potential direct action… read more here.
Keywords: pcsk9; promotes arterial; calcification; pro calcific ... See more keywords
Periostin Augments Vascular Smooth Muscle Cell Calcification via β-Catenin Signaling
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DOI: 10.3390/biom12081157
Abstract: Medial vascular calcification is common in chronic kidney disease (CKD) and is closely linked to hyperphosphatemia. Vascular smooth muscle cells (VSMCs) can take up pro-calcific properties and actively augment vascular calcification. Various pro-inflammatory mediators are… read more here.
Keywords: periostin; pro calcific; calcification; vascular smooth ... See more keywords
Ultrastructural and Immunohistochemical Detection of Hydroxyapatite Nucleating Role by rRNA and Nuclear Chromatin Derivatives in Aortic Valve Calcification: In Vitro and In Vivo Pro-Calcific Animal Models and Actual Calcific Disease in Humans
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032667
Abstract: Calcification starts with hydroxyapatite (HA) crystallization on cell membranous components, as with aortic valve interstitial cells (AVICs), wherein a cell-membrane-derived substance containing acidic phospholipids (PPM/PPLs) acts as major crystal nucleator. Since nucleic acid removal is… read more here.
Keywords: rrna nuclear; aortic valve; calcification; pro calcific ... See more keywords
Iron in Vascular Calcification: Pro-Calcific Agent or Protective Modulator?
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DOI: 10.3390/ijms262010210
Abstract: Vascular calcification is a complex, regulated process characterized by the pathological deposition of calcium phosphate minerals in the vascular wall, contributing to cardiovascular morbidity and mortality, particularly in patients with chronic kidney disease (CKD), diabetes,… read more here.
Keywords: calcification pro; pro calcific; iron vascular; vascular calcification ... See more keywords