Hypoxia-activated pro-drugs of the KDAC inhibitor vorinostat (SAHA)
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DOI: 10.1016/j.tet.2020.131170
Abstract: Abstract Hypoxia (lower than normal oxygen) is a characteristic of most solid tumours that results in poor cancer patient prognosis. The difference in cellular environment between normoxia (21% oxygen) or physoxia (4–7.5% oxygen) and hypoxia… read more here.
Keywords: hypoxia; pro drugs; kdac inhibitor; hypoxia activated ... See more keywords
Nanotherapeutics for neurosurgically-applied drug delivery
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DOI: 10.1093/neuonc/noz167.067
Abstract: Despite multimodal treatment, the median survival of Glioblastoma multiforme (GBM) remains less than 15 months, in considerable part due to diffusely infiltrative disease. Better treatment methods are necessary to eradicate residual tumour burden remaining beyond… read more here.
Keywords: neurosurgically applied; delivery; drug; pro drugs ... See more keywords