PDK4 suppresses high glucose-induced microglial ferroptosis by restricting pro-ferroptotic PUFA biosynthesis.
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DOI: 10.1097/wnr.0000000000002234
Abstract: BACKGROUND Diabetes significantly elevates the risk of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, indicating shared pathophysiological mechanisms. While ferroptosis is increasingly implicated in neurodegeneration, microglia - highly vulnerable to ferroptosis - may mediate… read more here.
Keywords: high glucose; induced microglial; microglial ferroptosis; ferroptosis ... See more keywords