Vitis vinifera polyphenols from seedless black fruit act synergistically to suppress hepatotoxicity by targeting necroptosis and pro-fibrotic mediators
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59489-z
Abstract: Human is subjected from his surrounding to various hepatotoxins, which aggravates his liver. Nowadays, natural polyphenols have attracted great interest in health improvement, especially liver health. The present research, therefore, assessed the hepatotherapeutic potency of… read more here.
Keywords: vitis vinifera; hepatotoxicity; pro fibrotic; necroptosis pro ... See more keywords
An alternative in vitro model considering cell-cell interactions in fiber-induced pulmonary fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology mechanisms and methods"
DOI: 10.1080/15376516.2022.2156008
Abstract: Abstract Particularly since the wide-ranging health effects of asbestos exposure became known, great emphasis has been placed on detailed toxicity testing of known but also newly developed fiber materials. Exposure to respirable pollutants like fibers… read more here.
Keywords: culture; cell; pulmonary fibrosis; pro fibrotic ... See more keywords
Tacrolimus induces a pro-fibrotic response in donor-derived human proximal tubule cells dependent on common variants of the CYP3A5 and ABCB1 genes
Sign Up to like & getrecommendations! Published in 2022 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfac237
Abstract: ABSTRACT Background Common genetic variants of the enzymes and efflux pump involved in tacrolimus disposition have been associated with calcineurin inhibitor nephrotoxicity, but their importance is unclear because of the multifactorial background of renal fibrosis.… read more here.
Keywords: fibrotic response; background; pro fibrotic; tacrolimus ... See more keywords
NOX5 EXPRESSION IN A VASCULAR SMOOTH MUSCLE CELL-SPECIFIC MANNER INDUCES FIBROBLAST PHENOTYPIC SWITCH AND PRO-FIBROTIC EFFECTS
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000835588.67477.1c
Abstract: Objective: Mice expressing human Nox5 (hNox5) in vascular smooth muscle cells (VSMC) exhibit redox-sensitive vascular dysfunction and cardio-renal fibrosis. Mechanisms underlying pro-fibrotic effects are unclear. Here we assessed whether hNox5 in VSMCs promotes fibroblast phenotypic… read more here.
Keywords: fibroblast phenotypic; expression; pro fibrotic; mice ... See more keywords
OP0167 B LYMPHOCYTES DIRECTLY CONTRIBUTE TO TISSUE FIBROSIS IN IGG4-RELATED DISEASE
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.1741
Abstract: Background IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition marked by rapid clinical improvement after selective depletion of B lymphocytes with rituximab. This feature suggests that B cells might participate in fibrogenesis and wound healing (1-3).… read more here.
Keywords: igg4; none declared; related disease; pro fibrotic ... See more keywords
Late-Breaking Basic Science Abstracts From the American Heart Association’s Scientific Sessions 2017
Sign Up to like & getrecommendations! Published in 2017 at "Circulation Research"
DOI: 10.1161/res.0000000000000184
Abstract: ### 24036 ### Inhibition Of Prolyl-tRNA Synthetase As A Novel Mediator Of Cardiac Fibrosis Joon Seok Park1, Caroline H Lee1, Sungjin Yoon1, Jong Hyun Kim2, Sunghoon Kim2, Bongyong Lee1; 1Daewoong Pharmaceutical Co., Ltd., Yongin, Korea,… read more here.
Keywords: prs; fibrosis; prolyl trna; cardiac fibrosis ... See more keywords
Abstract 529: Circulating Pro Fibrotic Protein Promotes Fibrosis in Liver and Heart
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.529
Abstract: Analyzing two sets of DNA micro array data with bioinformatics, we identified a secreted form pro-fibrotic protein (sPFP) expressed in dysfunctional brown adipose tissue (BAT) in mice. Testing our biobank samples, we found this protein… read more here.
Keywords: found spfp; model; spfp; pro fibrotic ... See more keywords
Small airway fibroblasts from COPD patients are senescent and pro-fibrotic
Sign Up to like & getrecommendations! Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2018.pa2172
Abstract: Background: Progressive small airway fibrosis is a key feature of early COPD. In COPD, cellular senescence levels are increased and may relate to disease progression. Peripheral parenchymal fibroblasts are pro-inflammatory and dysfunctional in COPD, but… read more here.
Keywords: senescence; airway fibroblasts; copd; small airway ... See more keywords
Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli
Sign Up to like & getrecommendations! Published in 2018 at "Respiratory Research"
DOI: 10.1186/s12931-018-0801-4
Abstract: BackgroundFibroblast apoptosis is a critical component of normal repair and the acquisition of an apoptosis-resistant phenotype contributes to the pathogenesis of fibrotic repair. Fibroblasts from fibrotic lungs of humans and mice demonstrate resistance to apoptosis… read more here.
Keywords: fas expression; apoptosis; fibroblast fas; expression ... See more keywords
CREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts
Sign Up to like & getrecommendations! Published in 2021 at "Respiratory Research"
DOI: 10.1186/s12931-021-01677-0
Abstract: Background Lysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors (LPARs) or sphingosine-1-phosphate receptors (S1PRs) to induce pro-fibrotic signaling in the lower respiratory tract of patients with… read more here.
Keywords: protein; lpa induced; induced signaling; small airway ... See more keywords
The IL-4/IL-13 signaling axis promotes prostatic fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0275064
Abstract: Background Lower urinary tract symptoms (LUTS) are a costly and pervasive medical problem for millions of aging men. Recent studies have showed that peri-urethral tissue fibrosis is an untreated pathobiology contributing to LUTS. Fibrosis results… read more here.
Keywords: expression; pro fibrotic; peri urethral; fibrosis ... See more keywords