Targeting transcriptional machinery to inhibit enhancer-driven gene expression in heart failure
Sign Up to like & getrecommendations! Published in 2019 at "Heart Failure Reviews"
DOI: 10.1007/s10741-019-09792-3
Abstract: Pathological cardiac remodeling is induced through multiple mechanisms that include neurohumoral and biomechanical stress resulting in transcriptional alterations that ultimately become maladaptive and lead to the development of heart failure (HF). Although cardiac transcriptional remodeling… read more here.
Keywords: transcriptional machinery; pro hypertrophic; heart failure;
TGF-β Signalling is Suppressed under Pro-Hypertrophic Conditions in MSC Chondrogenesis Due to TGF-β Receptor Downregulation
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Stem Cells"
DOI: 10.15283/ijsc18088
Abstract: Background and Objectives Mesenchymal stem cells (MSCs) become hypertrophic in long term despite chondrogenic differentiation following the pathway of growth plate chondrocytes. This terminal differentiation leads to phenotypically unstable cartilage and was mirrored in vitro… read more here.
Keywords: pro hypertrophic; hypertrophic conditions; tgf; hypertrophy ... See more keywords
Quercetin alleviates diastolic dysfunction and suppresses adverse pro-hypertrophic signaling in diabetic rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1029750
Abstract: Introduction Quercetin (Que) is a potent anti-inflammatory and antioxidant flavonoid with cardioprotective potential. However, very little is known about the signaling pathways and gene regulatory proteins Que may interfere with, especially in diabetic cardiomyopathy. Therefore,… read more here.
Keywords: diabetic rats; que; diastolic dysfunction; hypertrophic signaling ... See more keywords