Multifunctional Antibacterial Nanonets Attenuate Inflammatory Responses Through Selective Trapping of Endotoxins and Pro-Inflammatory Cytokines.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203232
Abstract: Extracellular lipopolysaccharide (LPS) released from bacteria cells can enter the bloodstream and cause septic complications with excessive host inflammatory responses. Target-specific strategies to inactivate inflammation mediators have largely failed to improve the prognosis of septic… read more here.
Keywords: inflammatory responses; nanonets attenuate; multifunctional antibacterial; inflammatory cytokines ... See more keywords
CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity
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DOI: 10.1002/advs.202103719
Abstract: The mechanism of obesity‐related metabolic dysfunction involves the development of systemic inflammation, largely mediated by macrophages. Switching of M1‐like adipose tissue macrophages (ATMs) to M2‐like ATMs, a population of macrophages associated with weight loss and… read more here.
Keywords: cd146; pro inflammatory; polarization; obesity ... See more keywords
A Balance between Pro‐Inflammatory and Pro‐Reparative Macrophages is Observed in Regenerative D‐MAPS
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DOI: 10.1002/advs.202204882
Abstract: Microporous annealed particle scaffolds (MAPS) are a new class of granular materials generated through the interlinking of tunable microgels, which produce an interconnected network of void space. These microgel building blocks can be designed with… read more here.
Keywords: inflammatory pro; pro reparative; reparative macrophages; pro inflammatory ... See more keywords
Effective inhibition of C3a-mediated pro-inflammatory response by a human C3a-specific protein binder.
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DOI: 10.1002/bit.27309
Abstract: Complement component 3a (C3a) plays a crucial role in the immune response and host defense, but it is also involved in pro-inflammatory responses, causing many inflammatory disorders. Blockade of C3a has been regarded as a… read more here.
Keywords: c3a; protein binder; response; specific protein ... See more keywords
Leishmania amazonensis from distinct clinical forms/hosts has polymorphisms in Lipophosphoglycans, displays variations in immunomodulatory properties and, susceptibility to antileishmanial drugs
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DOI: 10.1002/cbin.11880
Abstract: Lipophosphoglycan (LPG), the major Leishmania glycoconjugate, induces pro‐inflammatory/immunosuppressive innate immune responses. Here, we evaluated functional/biochemical LPG properties from six Leishmania amazonensis strains from different hosts/clinical forms. LPGs from three strains (GV02, BA276, and LV79) had… read more here.
Keywords: susceptibility antileishmanial; clinical forms; amazonensis; side chains ... See more keywords
Omentin‐regulated proteins combine a pro‐inflammatory phenotype with an anti‐inflammatory counterregulation in human adipocytes: A proteomics analysis
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3074
Abstract: Experimental and epidemiological studies reported controversial data on the role of omentin in type 2 diabetes and cardiovascular diseases. This study aimed to characterise the impact of omentin on the secretome of human adipocytes to… read more here.
Keywords: combine pro; omentin regulated; regulated proteins; proteins combine ... See more keywords
Musculin is highly enriched in Th17 and IL‐22‐producing ILC3s and restrains pro‐inflammatory cytokines in murine colitis
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DOI: 10.1002/eji.202048573
Abstract: The basic helix-loop-helix transcription factor Musculin (MSC, bHLHa22) is found to be highly enriched in pro-inflammatory Th17 cells, with levels correlated with stronger Th17 phenotypes. MSC is also significantly expressed in RORγt+ IL-22-producing group 3… read more here.
Keywords: musculin; highly enriched; colitis; inflammatory cytokines ... See more keywords
HAMLET a human milk protein‐lipid complex induces a pro‐inflammatory phenotype of myeloid cells
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DOI: 10.1002/eji.202048813
Abstract: HAMLET is a protein‐lipid complex with a specific and broad bactericidal and tumoricidal activity, that lacks cytotoxic activity against healthy cells. In this study, we show that HAMLET also has general immune‐stimulatory effects on primary… read more here.
Keywords: phenotype; protein lipid; lipid complex; hamlet stimulated ... See more keywords
Lipid transporter Spns2 promotes microglia pro‐inflammatory activation in response to amyloid‐beta peptide
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DOI: 10.1002/glia.23558
Abstract: Accumulating evidence indicates that neuroinflammation contributes to the pathogenesis and exacerbation of neurodegenerative disorders, such as Alzheimer's disease (AD). Sphingosine‐1‐phosphate (S1P) is a pleiotropic bioactive lipid that regulates many pathophysiological processes including inflammation. We present… read more here.
Keywords: promotes microglia; microglia pro; inflammatory activation; spns2 ... See more keywords
Imaging of translocator protein upregulation is selective for pro‐inflammatory polarized astrocytes and microglia
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DOI: 10.1002/glia.23716
Abstract: Translocator protein (TSPO) expression is increased in activated glia, and has been used as a marker of neuroinflammation in PET imaging. However, the extent to which TSPO upregulation reflects a pro‐ or anti‐inflammatory phenotype remains… read more here.
Keywords: astrocytes microglia; translocator protein; inflammatory; upregulation ... See more keywords
NR1H3 (LXRα) is associated with pro‐inflammatory macrophages, predicts survival and suggests potential therapeutic rationales in diffuse large b‐cell lymphoma
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DOI: 10.1002/hon.3050
Abstract: The role of macrophages (Mo) and their prognostic impact in diffuse large B‐cell lymphomas (DLBCL) remain controversial. By regulating the lipid metabolism, Liver‐X‐Receptors (LXRs) control Mo polarization/inflammatory response, and their pharmacological modulation is under clinical… read more here.
Keywords: large cell; nr1h3 lxr; diffuse large; pro inflammatory ... See more keywords