Mass spectrometric assays reveal discrepancies in inhibition profiles for the SARS-CoV-2 papain-like protease.
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DOI: 10.1002/cmdc.202200016
Abstract: The two SARS-CoV-2 proteases, i.e. the main protease (M pro ) and the papain-like protease (PL pro ), which hydrolyze the viral polypeptide chain giving functional non-structural proteins, are essential for viral replication and are… read more here.
Keywords: pro inhibitors; sars cov; mass; papain like ... See more keywords
Short divalent ethacrynic amides as pro-inhibitors of glutathione S-transferase isozyme Mu and potent sensitisers of cisplatin-resistant ovarian cancers
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DOI: 10.1080/14756366.2022.2038591
Abstract: Abstract The linking of ethacrynic acid with ethylenediamine and 1,4-butanediamine gave EDEA and BDEA, respectively, as membrane-permeable divalent pro-inhibitors of glutathione S-transferase (GST). Their divalent glutathione conjugates showed subnanomolar inhibition and divalence-binding to GSTmu (GSTM)… read more here.
Keywords: inhibitors glutathione; glutathione transferase; pro inhibitors; ovarian cancers ... See more keywords