Serum-soluble (pro)renin receptor concentration as a biomarker for organ damage in primary aldosteronism
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension Research"
DOI: 10.1038/s41440-019-0312-9
Abstract: Primary aldosteronism is characterized by inappropriate overproduction of aldosterone by adrenal lesions and leads to hypertension. Excess aldosterone causes organ damage; therefore, finding a biomarker for organ damage risk is vital. The (pro)renin receptor regulates… read more here.
Keywords: renin; renin receptor; organ damage; pro renin ... See more keywords
The (pro)renin receptor: what’s in a name?
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-020-0274-9
Abstract: A. Ichihara and M. S. Yatabe (The (pro)renin receptor in health and disease. Nat. Rev. Nephrol. 15, 693–712 (2019))1. The (pro)renin receptor (PRR; also known as ATP6AP2) was first discovered in 1998 in a biochemical… read more here.
Keywords: medicine; renin; name; renin receptor ... See more keywords
Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-88665-y
Abstract: The (pro)renin receptor (PRR) is a multifunctional integral membrane protein that serves as a component of the vacuolar H+-ATPase (V-ATPase) and also activates (pro)renin. We recently showed that full-length PRR, found as part of a… read more here.
Keywords: extracellular vesicles; pro renin; vesicles osteoclasts; prr ... See more keywords
Pro)renin Receptor RNA Interference Silencing Attenuates Diabetic Cardiomyopathy Pathological Process in Rats
Sign Up to like & getrecommendations! Published in 2019 at "Human Gene Therapy"
DOI: 10.1089/hum.2018.155
Abstract: (Pro)renin receptor (PRR) is a novel component of the renin–angiotensin system that has been demonstrated to be involved in cardiovascular diseases. Recent research reported that diabetic cardiomyo... read more here.
Keywords: pro renin; receptor rna; rna interference; interference silencing ... See more keywords
Revisiting the relationship between (Pro)Renin receptor and the intrarenal RAS: focus on the soluble receptor
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000806
Abstract: Purpose of review The (pro)renin receptor (PRR), also termed as ATPase H+ transporting accessory protein 2 (ATP6AP2), was originally cloned as a specific receptor for prorenin and renin [together called (pro)renin]. Given the wide tissue… read more here.
Keywords: renin receptor; prr; renin; receptor ... See more keywords
Enhanced Intrarenal pro-renin and salt sensitive hypertension in a mouse model of Type-1 diabetes
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735218
Abstract: Hypertension affects up to 50% of patients with type 1 diabetes. Despite aggressive anti-hypertensive therapy, at least 30% of diabetic patients develop chronic kidney disease. Renin is the rate-limiting enzyme in the activation of the… read more here.
Keywords: hypertension; physiology; renin; akita mice ... See more keywords
Neuronal (pro)renin receptor regulates deoxycorticosterone-induced sodium intake.
Sign Up to like & getrecommendations! Published in 2018 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00065.2018
Abstract: Increased sodium appetite is a physiological response to sodium deficiency; however, it has also been implicated in disease conditions such as congestive heart failure, kidney failure, and salt-sensitive hypertension. The central nervous system is the… read more here.
Keywords: sodium intake; sodium; renin receptor; pro renin ... See more keywords
Soluble (pro)renin receptor level in patients with severe obesity is associated with visceral adiposity and is involved with insulin resistance and renal injury.
Sign Up to like & getrecommendations! Published in 2023 at "Obesity facts"
DOI: 10.1159/000531076
Abstract: INTRODUCTION High soluble (pro)renin receptor (s(P)RR) level in circulation is reported in obese patients; however, it is unclear which body composition components are responsible for it. In this study, the authors examined blood s(P)RR levels… read more here.
Keywords: soluble pro; renin receptor; receptor level; level ... See more keywords
Abstract P2019: (Pro)Renin Receptor-Dependent Induction of Pro-Fibrotic Factors is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Mouse Renal Collecting Duct Cells
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hyp.74.suppl_1.p2019
Abstract: The binding of prorenin to the (pro)renin receptor (PRR) stimulates MAPK/ERK1/2, cyclooxygenase-2 (COX-2), NOX-4-dependent production of reactive oxygen species (ROS), transforming growth factor-β (TGF-β), pro-fibrotic factors connecting tissue growth factor (CTGF), and plasminogen activator inhibitor… read more here.
Keywords: cox; pro renin; smad pathway; receptor ... See more keywords
Serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Endocrine Society"
DOI: 10.21203/rs.3.rs-379462/v1
Abstract: The (pro)renin receptor [(P)RR)] is a multifunctional protein that is cleaved to generate the soluble (P)RR [s(P)RR], reflecting the status of the tissue renin-angiotensin system and/or activity of the (P)RR. The serum s(P)RR level is… read more here.
Keywords: serum; pro renin; level; patients undergoing ... See more keywords
The role of (pro)renin receptor and its soluble form in cardiovascular diseases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2023.1086603
Abstract: The renin-angiotensin system (RAS) is a major classic therapeutic target for cardiovascular diseases. In addition to the circulating RAS, local tissue RAS has been identified in various tissues and plays roles in tissue inflammation and… read more here.
Keywords: soluble form; cardiovascular diseases; renin receptor; pro renin ... See more keywords