Concise Review: Pro-Resolving Lipid Mediators and Receptors in Stem Cell Biology.
Sign Up to like & getrecommendations! Published in 2019 at "Stem cells translational medicine"
DOI: 10.1002/sctm.19-0078
Abstract: Accumulating evidence indicates that stem cells (SCs) possess immunomodulatory, anti-inflammatory, and pro-healing properties. The mechanisms underlying these functions are being investigated with the final goal to set a solid background for the clinical use of… read more here.
Keywords: medicine; resolving lipid; pro resolving; lipid mediators ... See more keywords
The Evolving Role of Specialized Pro-resolving Mediators in Modulating Neuroinflammation in Perioperative Neurocognitive Disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-21735-8_4
Abstract: Surgery can be a life-saving procedure; however, significant complications may occur after routine procedures especially in older and more frail patients. Perioperative neurocognitive disorders (PNDs), including delirium and postoperative cognitive dysfunction, are the most common… read more here.
Keywords: specialized pro; perioperative neurocognitive; pro resolving; role ... See more keywords
Cerebrospinal Fluid Profile of Lipid Mediators in Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-022-01216-5
Abstract: Alzheimer's disease (AD) develops into dementia over a period of several years, during which subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) can be used as intermediary diagnoses of increasing severity. Chronic neuroinflammation resulting… read more here.
Keywords: pro resolving; cerebrospinal fluid; lipid mediators; alzheimer disease ... See more keywords
A Docosahexaenoic Acid-Derived Pro-resolving Agent, Maresin 1, Protects Motor Neuron Cells Death
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2556-1
Abstract: Maresin 1 is a novel pro-resolving mediator derived from docosahexaenoic acid (DHA), with potent anti-inflammation effects against several animal models, including brain ischemia, sepsis, and lung fibrosis. However, its effect against motor neuron cell death… read more here.
Keywords: death; pro resolving; motor neuron; stress ... See more keywords
Enzymatic studies with 3-oxa n-3 DPA.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103653
Abstract: Cyclooxygenase-2 and several lipoxygenases convert polyunsaturated fatty acids into a large variety of products. During inflammatory processes, these enzymes form several distinct families of specialized pro-resolving lipid mediators possessing potent anti-inflammatory and pro-resolving effects. These… read more here.
Keywords: studies oxa; pro resolving; chemistry; enzymatic studies ... See more keywords
Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108247
Abstract: SUMMARY Underlying mechanisms of how infectious inflammation is resolved by the host are incompletely understood. One hallmark of inflammation resolution is the activation of specialized pro-resolving mediators (SPMs) that enhance bacterial clearance and promote tissue… read more here.
Keywords: specialized pro; resolution; pro resolving; inflammation resolution ... See more keywords
Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109201
Abstract: SUMMARY The chronic neuro-inflammatory character of multiple sclerosis (MS) suggests that the natural process to resolve inflammation is impaired. This protective process is orchestrated by specialized pro-resolving lipid mediators (SPMs), but to date, the role… read more here.
Keywords: resolving lipid; pro resolving; inflammation; cord lipidome ... See more keywords
Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.07.024
Abstract: Background Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as specialized pro-resolving mediators (SPM). These mediators also provide novel therapeutic opportunities for treating… read more here.
Keywords: specialized pro; pro resolving; lipid mediators; myocardial infarction ... See more keywords
Low levels of pro-resolving lipid mediators lipoxin-A4, resolvin-D1 and resolvin-E1 in patients with rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2020 at "Immunology letters"
DOI: 10.1016/j.imlet.2020.08.006
Abstract: Rheumatoid arthritis (RA) is a disease in which joint inflammation is at the forefront but the whole body is affected, and prevention of inflammation is the main treatment approach. Lipoxins (LXs) and resolvins (Rvs) are… read more here.
Keywords: resolving lipid; levels pro; pro resolving; lipid mediators ... See more keywords
Specialized pro-resolving mediators in cardiovascular diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2017.02.003
Abstract: The resolution of inflammation is a highly regulated process enacted by endogenous mediators including specialized pro-resolving lipid mediators (SPMs): the lipoxins, resolvins, protectins and maresins. SPMs activate specific cellular receptors to temper the production of… read more here.
Keywords: specialized pro; resolving mediators; pro resolving; inflammation ... See more keywords
New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2017.08.002
Abstract: While protective, the acute inflammatory response when uncontrolled can lead to further tissue damage and chronic inflammation that is now widely recognized to play important roles in many commonly occurring diseases, such as cardiovascular disease,… read more here.
Keywords: resolution; pro resolving; tissue regeneration; regeneration ... See more keywords