Inhibition of Pro‐Survival Autophagy Induced by Rare‐Earth Nanocomposites for Promoting Photothermal Therapy of Visualized Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202117
Abstract: Manipulation of autophagic processes has emerged as a promising strategy for synergizing nanoagent‐mediated photothermal therapy (PTT). Most of the current studies focus on improving PTT efficacy by inhibiting pro‐survival autophagy induced by the heat generated… read more here.
Keywords: survival autophagy; photothermal therapy; pro survival; autophagy ... See more keywords
Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108678
Abstract: Osteosarcoma is the most common pediatric and adult primary malignant bone cancer. Curative regimens target the folate pathway, downstream of serine metabolism, with high-dose methotrexate. Here, the rate-limiting enzyme in the biosynthesis of serine from… read more here.
Keywords: pro survival; phosphoglycerate dehydrogenase; mtorc1 signaling; inhibition ... See more keywords
Pro-Death or Pro-Survival: Contrasting Paradigms on Nanomaterial-Induced Autophagy and Exploitations for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.9b00397
Abstract: Autophagy is a critical lysosome-mediated cellular degradation process for the clearance of damaged organelles, obsolete proteins, and invading pathogens and plays important roles in the pathogenesis and treatment of human diseases including cancer. While not… read more here.
Keywords: pro survival; death; pro death; nanomaterial induced ... See more keywords
SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas
Sign Up to like & getrecommendations! Published in 2020 at "Blood Cancer Journal"
DOI: 10.1038/s41408-020-0277-6
Abstract: Activating MYD88 mutations promote pro-survival signaling through BTK and HCK, both targets of ibrutinib. Despite high response rates, complete responses to ibrutinib are lacking, and other MYD88 triggered pro-survival pathways may contribute to primary drug… read more here.
Keywords: pro survival; mutated myd88; syk; myd88 mutated ... See more keywords
Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00839-3
Abstract: Inflammation is a natural defence mechanism of the body to protect against pathogens. It is induced by immune cells, such as macrophages and neutrophils, which are rapidly recruited to the site of infection, mediating host… read more here.
Keywords: pro survival; cell; inflammatory cells; inflammation ... See more keywords
What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy?
Sign Up to like & getrecommendations! Published in 2022 at "Cell death and differentiation"
DOI: 10.1038/s41418-022-00987-0
Abstract: In many human cancers the control of apoptosis is dysregulated, for instance as a result of the overexpression of pro-survival BCL-2 proteins. This promotes tumorigenesis by protecting nascent neoplastic cells from stress and renders malignant… read more here.
Keywords: bh3 mimetic; survival bcl; bcl; bcl proteins ... See more keywords
GRP94 promotes brain metastasis by engaging pro-survival autophagy.
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-oncology"
DOI: 10.1093/neuonc/noz198
Abstract: BACKGROUND GRP94 is a glucose-regulated protein critical for survival in endoplasmic reticulum stress. Expression of GRP94 is associated with cellular transformation and increased tumorigenicity in breast cancer. Specifically, over-expression of GRP94 predicts brain metastasis in… read more here.
Keywords: pro survival; autophagy; brain metastasis; grp94 ... See more keywords
Aging differentially modulates the Wnt pro‐survival signalling pathways in vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Aging Cell"
DOI: 10.1111/acel.12844
Abstract: We previously reported pro‐survival effects of Wnt3a and Wnt5a proteins in vascular smooth muscle cells (VSMCs). Wnt5a achieved this through induction of Wnt1‐inducible signalling pathway protein‐1 (WISP‐1) consequent to β‐catenin/CREB‐dependent, TCF‐independent, signalling. However, we found… read more here.
Keywords: pro survival; vascular smooth; muscle cells; smooth muscle ... See more keywords
IFN-γ regulates a complex pro-survival signal network in CLL.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of haematology"
DOI: 10.1111/ejh.13921
Abstract: BACKGROUND It is known that the microenvironmental cytokine IFN-γ provides a survival advantage for CLL cells. However, the mechanisms involved in this effect have not been properly investigated. METHODS Herein, we conducted a comprehensive screening… read more here.
Keywords: ifn regulates; complex pro; signal; regulates complex ... See more keywords
Pro‐survival redox signalling in progesterone‐mediated retinal neuroprotection
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.13604
Abstract: Retinitis pigmentosa (RP) is a group of hereditary retinal diseases, characterised by photoreceptor cell loss. Despite a substantial understanding of the mechanisms leading to cell death, an effective therapeutic strategy is sought. Our laboratory has… read more here.
Keywords: pro survival; redox signalling; survival redox; progesterone ... See more keywords
Role of PI3K in myocardial ischaemic preconditioning: mapping pro‐survival cascades at the trigger phase and at reperfusion
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13394
Abstract: The Reperfusion Injury Salvage Kinase (RISK) pathway is considered the main pro‐survival kinase cascade mediating the ischaemic preconditioning (IPC) cardioprotective effect. To assess the role of PI3K‐Akt, its negative regulator PTEN and other pro‐survival proteins… read more here.
Keywords: pro survival; ipc; ischaemic preconditioning; reperfusion ... See more keywords