FAK inhibitors induce cell multinucleation and dramatically increase pro‐tumoral cytokine expression in RAW 264.7 macrophages
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12895
Abstract: Macrophages are abundant in the tumor microenvironment. They are highly plastic and able to acquire pro‐tumoral phenotypes in response to microenvironmental stimuli. When we treated RAW 264.7 macrophages with inhibitors of various oncogenic pathways, we… read more here.
Keywords: raw 264; fak inhibitors; cell multinucleation; pro tumoral ... See more keywords
IL-18 and VEGF-A trigger type 2 innate lymphoid cell accumulation and pro-tumoral function in chronic myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2023 at "Haematologica"
DOI: 10.3324/haematol.2022.282140
Abstract: Chronic Myeloid Leukemia (CML) is a hematologic malignancy associated to an unregulated growth of myeloid cells in Bone Marrow (BM) and Peripheral Blood (PB), characterized by the BCR-ABL1 translocation. Given the known cytokine impairment in… read more here.
Keywords: myeloid leukemia; chronic myeloid; pro tumoral; myeloid ... See more keywords
Dual Face of Vγ9Vδ2-T Cells in Tumor Immunology: Anti- versus Pro-Tumoral Activities
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.01041
Abstract: Vγ9Vδ2-T cells are considered as potent effector cells for tumor immunotherapy through directly killing tumor cells and indirectly regulating other innate and adaptive immune cells to establish antitumoral immunity. The antitumoral activity of Vγ9Vδ2-T cells… read more here.
Keywords: tumoral activities; anti versus; immunology; cells tumor ... See more keywords
Senescent Thyrocytes, Similarly to Thyroid Tumor Cells, Elicit M2-like Macrophage Polarization In Vivo
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DOI: 10.3390/biology10100985
Abstract: Simple Summary Several studies including ours suggest a pro-tumoral role of senescent thyrocytes in thyroid tumors. On the other hand, M2-like tumor associated macrophages infiltration increases with thyroid cancer aggressiveness. In this work, we used… read more here.
Keywords: senescent thyrocytes; macrophage; thyroid tumor; pro tumoral ... See more keywords
Identification of uPAR Variants Acting as ceRNAs in Leukaemia Cells
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DOI: 10.3390/cancers14081980
Abstract: Simple Summary The urokinase (uPA) receptor (uPAR) concentrates proteolytic activities on the cell surface and is an adhesion receptor for vitronectin. Urokinase/Vitronectin binding to uPAR activates intracellular signals promoting cell adhesion, migration, proliferation and survival.… read more here.
Keywords: leukaemia; pro tumoral; upar mrna; upar variants ... See more keywords