Pro-tumorigenic functions of macrophages at the primary, invasive and metastatic tumor site
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02616-6
Abstract: The tumor microenvironment (TME) not only facilitates cancer progression from the early formation to distant metastasis, but also it differs itself from time to time alongside the tumor evolution. Tumor-associated macrophages (TAMs), whether as pre-existing… read more here.
Keywords: pro tumorigenic; macrophages primary; functions macrophages; cancer ... See more keywords
CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.25
Abstract: CTCF is a haploinsufficient tumour suppressor gene with diverse normal functions in genome structure and gene regulation. However the mechanism by which CTCF haploinsufficiency contributes to cancer development is not well understood. CTCF is frequently… read more here.
Keywords: pro tumorigenic; ctcf genetic; ctcf haploinsufficiency; genetic alterations ... See more keywords
YME1L overexpression exerts pro-tumorigenic activity in glioma by promoting Gαi1 expression and Akt activation
Sign Up to like & getrecommendations! Published in 2022 at "Protein & Cell"
DOI: 10.1093/procel/pwac011
Abstract: Identifying novel glioma-driven signaling molecules and explor-ing the corresponding molecularly targeted therapies read more here.
Keywords: pro tumorigenic; tumorigenic activity; exerts pro; glioma ... See more keywords
NOD2 deficiency confers a pro‐tumorigenic macrophage phenotype to promote lung adenocarcinoma progression
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16790
Abstract: Nucleotide‐binding and oligomerization domain‐containing protein 2 (NOD2) was a member of the NOD‐like receptor family and played an important role in the innate immune response. Dysregulated NOD2 had been reported to contribute to tumorigenesis and… read more here.
Keywords: lung adenocarcinoma; progression; pro tumorigenic; nod2 deficiency ... See more keywords
Abstract 3652: Circular RNAs repress interferon responses in the sarcoma cells and promote sarcoma growth by forging a pro-tumorigenic immune microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3652
Abstract: Circular RNAs (CircRNA) arise from events of non-conventional splicing in which the 3'-tail of an exon back-splices and joins the 5'-head of the upstream exon. Because of their structural conformation, these RNAs are incredibly stable… read more here.
Keywords: pro tumorigenic; promote sarcoma; sarcoma growth; circular rnas ... See more keywords
miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Oncotarget"
DOI: 10.18632/oncotarget.27614
Abstract: Many cancers maintain an inflammatory microenvironment to promote their growth. Lung cancer is of particular importance, as it is the deadliest cancer worldwide. One inflammatory pathway commonly dysregulated in cancer is the metabolism of arachidonic… read more here.
Keywords: pro tumorigenic; lung cancer; mir 708; cancer cells ... See more keywords
Pharmacological Targeting of STING-Dependent IL-6 Production in Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.709618
Abstract: Activation of the STING pathway upon genotoxic treatment of cancer cells has been shown to lead to anti-tumoral effects, mediated through the acute production of interferon (IFN)-β. Conversely, the pathway also correlates with the expression… read more here.
Keywords: pro tumorigenic; cancer cells; dna damage; canonical sting ... See more keywords
The Pro-tumorigenic IL-33 Involved in Antitumor Immunity: A Yin and Yang Cytokine
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02506
Abstract: Interleukin-33 (IL-33), considered as an alarmin released upon tissue stress or damage, is a member of the IL-1 family and binds the ST2 receptor. First described as a potent initiator of type 2 immune responses… read more here.
Keywords: pro tumorigenic; antitumor immunity; tumorigenic involved; involved antitumor ... See more keywords
The Anti- and Pro-Tumorigenic Role of Microbiota and Its Role in Anticancer Therapeutic Strategies
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers15010190
Abstract: Simple Summary Human gut is colonized by a wide variety of microorganisms, which collectively form the so-called microbiota. A healthy microbiota interacts with our organism as a symbiont positively participating in the regulation of many… read more here.
Keywords: pro tumorigenic; gut; microbiota; role ... See more keywords
Exosomes as Emerging Pro-Tumorigenic Mediators of the Senescence-Associated Secretory Phenotype
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20102547
Abstract: Communication between cells is quintessential for biological function and cellular homeostasis. Membrane-bound extracellular vesicles known as exosomes play pivotal roles in mediating intercellular communication in tumor microenvironments. These vesicles and exosomes carry and transfer biomolecules… read more here.
Keywords: secretory phenotype; pro tumorigenic; senescence associated; senescent cells ... See more keywords
Disabled-2 (DAB2): A Key Regulator of Anti- and Pro-Tumorigenic Pathways
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010696
Abstract: Disabled-2 (DAB2), a key adaptor protein in clathrin mediated endocytosis, is implicated in the regulation of key signalling pathways involved in homeostasis, cell positioning and epithelial to mesenchymal transition (EMT). It was initially identified as… read more here.
Keywords: pro tumorigenic; disabled dab2; key regulator; dab2 key ... See more keywords