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Published in 2023 at "American journal of epidemiology"
DOI: 10.1093/aje/kwad054
Abstract: Protocol adherence may influence measured treatment effectiveness in randomized controlled trials. Using data from a multicenter trial from Europe and North and South America in 2002-2009 of children with HIV-1 randomized to initial protease inhibitor…
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Keywords:
per protocol;
probability censoring;
nnrti regimens;
inverse probability ... See more keywords
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Published in 2019 at "Statistical Methods in Medical Research"
DOI: 10.1177/0962280217735560
Abstract: Background When trials are subject to departures from randomised treatment, simple statistical methods that aim to estimate treatment efficacy, such as per protocol or as treated analyses, typically introduce selection bias. More appropriate methods to…
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Keywords:
inverse probability;
treatment;
probability censoring;
time ... See more keywords
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1
Published in 2022 at "Statistical Methods in Medical Research"
DOI: 10.1177/09622802221090763
Abstract: Inverse probability of censoring weighting is a popular approach to handling dropout in longitudinal studies. However, inverse probability-of-censoring weighted estimators (IPCWEs) can be inefficient and unstable if the weights are estimated by maximum likelihood. To…
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Keywords:
probability censoring;
sensitivity;
sensitivity analysis;
ignorable dropout ... See more keywords