Population pharmacokinetics and probability of target attainment in patients with sepsis under renal replacement therapy receiving continuous infusion of meropenem: sustained low-efficiency dialysis (SLED) and continuous veno-venous haemodialysis (CVVHD).
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DOI: 10.1111/bcp.14846
Abstract: AIM To describe the population pharmacokinetics (popPK) and probability of target attainment (PTA) of continuous infusion (CI) of meropenem in septic patients receiving renal replacement therapy (RRT). METHODS Fiveteen patients without RRT, 13 patients receiving… read more here.
Keywords: probability target; infusion meropenem; cvvhd; target ... See more keywords
Factoring fu Variability Into Estimates of Unbound Drug Concentrations Negatively Biases the MIC Versus % Probability of Target Attainment Relationship of Antimicrobial Agents.
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DOI: 10.1111/jvp.13498
Abstract: The clinical breakpoint for a drug-pathogen combination reflects the drug susceptibility of the pathogen wild-type population, the location of the infection, the integrity of the host immune response, and the drug-pathogen pharmacokinetic (PK)/pharmacodynamic (PD) relationship.… read more here.
Keywords: relationship; probability target; variability; drug ... See more keywords
Population Pharmacokinetics of Levofloxacin and Moxifloxacin, and the Probability of Target Attainment in Ethiopian Patients with Multidrug-Resistant Tuberculosis
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DOI: 10.2147/idr.s389442
Abstract: Objective This study aimed to explore the population pharmacokinetic modeling (PopPK) of levofloxacin (LFX) and moxifloxacin (MXF), as well as the percent probability of target attainment (PTA) as defined by the ratio of the area… read more here.
Keywords: target attainment; resistant tuberculosis; probability target; resistance ... See more keywords
Beta-Lactam Probability of Target Attainment Success: Cefepime as a Case Study
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DOI: 10.3390/antibiotics12030444
Abstract: Introduction: Probability of target attainment (PTA) analysis using Monte Carlo simulations has become a mainstay of dose optimization. We highlight the technical and clinical factors that may affect PTA for beta-lactams. Methods: We performed a… read more here.
Keywords: cefepime; success; probability target; pta ... See more keywords
All Roads Lead to Rome: Enhancing the Probability of Target Attainment with Different Pharmacokinetic/Pharmacodynamic Modelling Approaches
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DOI: 10.3390/antibiotics12040690
Abstract: In light of rising antimicrobial resistance and a decreasing number of antibiotics with novel modes of action, it is of utmost importance to accelerate development of novel treatment options. One aspect of acceleration is to… read more here.
Keywords: lead rome; probability target; roads lead; target attainment ... See more keywords