Probenecid increases renal retention and antitumor activity of DFMO in neuroblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-021-04309-y
Abstract: Neuroblastoma (NB) is the most common extracranial solid tumor in children. Interference with the polyamine biosynthesis pathway by inhibition of MYCN-activated ornithine decarboxylase (ODC) is a validated approach. The ODC inhibitor α-difluoromethylornithine (DFMO, or Eflornithine)… read more here.
Keywords: probenecid; activity dfmo; dfmo; antitumor activity ... See more keywords
Highly luminescent dinuclear terbium-probenecid cluster as an ultra-sensitive probe for AFP
Sign Up to like & getrecommendations! Published in 2020 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2020.108738
Abstract: Abstract It is generally accepted that the cancer should be treated as early as possible, thus, the cancer biomarker detection is of great significance, especially for the ultra-low concentration cancer biomarker. In this work, a… read more here.
Keywords: probenecid cluster; probenecid; cancer; dinuclear terbium ... See more keywords
Resveratrol glucuronidation in vitro: potential implications of inhibition by probenecid
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.13037
Abstract: Resveratrol is a naturally occurring antioxidant with therapeutic potential in prevention and treatment of neoplastic disease and other human disorders. However, net clearance of resveratrol in humans is very high, mainly due to glucuronide conjugation.… read more here.
Keywords: resveratrol; vitro potential; resveratrol glucuronidation; probenecid ... See more keywords
Detection of Weak Organic Anion–Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans
Sign Up to like & getrecommendations! Published in 2020 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.120.000076
Abstract: Probenecid (PROB) is a clinical probe inhibitor of renal organic anion transporter (OAT) 1 and OAT3 that inhibits in vitro activity of hepatic drug transporters OATP1B1 and OATP1B3. It was hypothesized that PROB could potentially… read more here.
Keywords: fold fold; prob; inhibition; drug ... See more keywords
Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0180280
Abstract: Background There are no therapies shown to improve outcome after severe traumatic brain injury (TBI) in humans, a leading cause of morbidity and mortality. We sought to verify brain exposure of the systemically administered antioxidant… read more here.
Keywords: treatment; severe traumatic; probenecid; brain injury ... See more keywords
Probenecid slows disease progression in a murine model of autosomal dominant polycystic kidney disease
Sign Up to like & getrecommendations! Published in 2023 at "Physiological Reports"
DOI: 10.14814/phy2.15652
Abstract: Development of autosomal dominant polycystic kidney disease (ADPKD) involves renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other effects, leads to a reduced reabsorption of electrolytes in cyst‐lining cells,… read more here.
Keywords: pannexin; polycystic kidney; autosomal dominant; kidney disease ... See more keywords