Proteome‐Wide Identification of On‐ and Off‐Targets of Bcl‐2 Inhibitors in Native Biological Systems by Using Affinity‐Based Probes (AfBPs)
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DOI: 10.1002/cbic.201800380
Abstract: Selective inhibition of proteins of the Bcl‐2 family by small‐molecule inhibitors is a promising new approach in drug discovery. However, information about how these molecules interact with their cellular targets (on‐ and off‐) is highly… read more here.
Keywords: probes afbps; targets bcl; bcl inhibitors; affinity based ... See more keywords