Designed helical peptides as functional probes for γ-secretase.
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DOI: 10.1021/acs.biochem.9b00639
Abstract: γ-Secretase is a membrane-embedded aspartyl protease complex with presenilin as the catalytic component that cleaves within the transmembrane domain (TMD) of >90 known substrates, including the amyloid precursor protein (APP) of Alzheimer's disease. Processing by… read more here.
Keywords: helical peptides; functional probes; app; probes secretase ... See more keywords