Genetically-encoded BRET probes shed light on ligand bias–induced variable ion selectivity in TRPV1 and P2X5/7
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DOI: 10.1073/pnas.2205207119
Abstract: Significance Thanks to innovative BRET-based probes, we shed light on ligand-biased ion selectivity, a difficult-to-study ion channel–related pharmacological concept, by performing the dynamic measurements of Ca2+ and K+ concentrations and ionic strength in the nanoenvironment… read more here.
Keywords: ligand; light ligand; shed light; selectivity ... See more keywords