Probing the Mechanism of Photoaffinity Labeling by Dialkyldiazirines through Bioorthogonal Capture of Diazoalkanes.
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DOI: 10.1021/acs.orglett.0c02714
Abstract: Dialkyldiazirines have emerged as reagents of choice for biological photoaffinity labeling studies. The mechanism of crosslinking has dramatic consequences for biological applications where instantaneous labeling is desirable, as carbene insertions display different chemoselectivity and are… read more here.
Keywords: mechanism photoaffinity; probing mechanism; photoaffinity; diazo ... See more keywords