Problematic ArF–Alkynyl Coupling with Fluorinated Aryls. From Partial Success with Alkynyl Stannanes to Efficient Solutions via Mechanistic Understanding of the Hidden Complexity
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DOI: 10.1021/jacs.2c10842
Abstract: The synthesis of aryl–alkynyl compounds is usually achieved via Sonogashira catalysis, but this is inefficient for fluorinated aryls. An alternative method reported by Shirakawa and Hiyama, using alkynylstannanes and hemilabile PN ligands, works apparently fine… read more here.
Keywords: fluorinated aryls; alkynyl; problematic arf; arf alkynyl ... See more keywords