A lysozyme corona complex for the controlled pharmacokinetic release of probucol from mesoporous silica particles.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials science"
DOI: 10.1039/d0bm00445f
Abstract: Mesoporous silica particles (MSPs) enhance the release kinetics of poorly soluble compound probucol (PB) under the influence of a pore-blocking protein corona, prepared with lysozyme protein adsorption. In vivo oral administration experiments show a prolongation… read more here.
Keywords: mesoporous silica; corona; probucol; silica particles ... See more keywords
From jeopardy champion to drug discovery; semantic similarity artificial intelligence.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2210995
Abstract: We have employed artificial intelligence to streamline the small molecule drug screening pipeline and identified the cholesterol-reducing compound probucol in the process. Probucol augmented mitophagy and prevented loss of dopaminergic neurons in flies and zebrafish… read more here.
Keywords: jeopardy champion; artificial intelligence; drug; probucol ... See more keywords
Inhibitory effects and mechanism of probucol on elastase-induced abdominal aortic aneurysm in mice.
Sign Up to like & getrecommendations! Published in 2019 at "British journal of pharmacology"
DOI: 10.1111/bph.14857
Abstract: BACKGROUND AND PURPOSE Abdominal aortic aneurysm (AAA) is a degenerative disease with irreversible and progressive dilation of the artery. But there are few options for efficacious treatment except for traditional surgery. Probucol (PB) has been… read more here.
Keywords: inhibitory effects; elastase; aortic aneurysm; probucol ... See more keywords
An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3001977
Abstract: Failures in mitophagy, a process by which damaged mitochondria are cleared, results in neurodegeneration, while enhancing mitophagy promotes the survival of dopaminergic neurons. Using an artificial intelligence platform, we employed a natural language processing approach… read more here.
Keywords: lipid droplets; mitochondrial damage; mitophagy; probucol ... See more keywords
An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0214984
Abstract: Type 2 diabetes (T2D) is characterised by β-cell damage and hyperglycaemia. The lipophilic drug, probucol, has shown significant β-cell protective and potential antidiabetic effects, which were enhanced by hydrophilic bile acid incorporation using taurocholic acid… read more here.
Keywords: accumulation; probucol; bile acid; drug probucol ... See more keywords