Taurine Prevented Hypoxia Induced Chicken Cardiomyocyte Apoptosis Through the Inhibition of Mitochondrial Pathway Activated by Calpain-1.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8023-5_42
Abstract: Objective To determine whether taurine has protective effects on chicken myocardial apoptosis induced by hypoxic condition through inhibiting calpain-1 derived mitochondrial apoptotic pathway. Methods Chicken primary embryonic myocardial cells were isolated and cultured at 37 °C… read more here.
Keywords: chicken cardiomyocyte; apoptosis; inhibition; cardiomyocyte apoptosis ... See more keywords
Human procaspase-2 phosphorylation at both S139 and S164 is required for 14-3-3 binding.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.116
Abstract: Procaspase-2 phosphorylation at several residues prevents its activation and blocks apoptosis. This process involves procaspase-2 phosphorylation at S164 and its binding to the scaffolding protein 14-3-3. However, bioinformatics analysis has suggested that a second phosphoserine-containing… read more here.
Keywords: required binding; phosphorylation; s164; procaspase phosphorylation ... See more keywords
The M476W/Q482H mutation of procaspase-8 restored caspase-8-mediated apoptosis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.023
Abstract: Caspase-8 is an initiator of apoptotic signalling, and aberrations in procaspase-8 have been verified to be associated with malignant tumours. In previous studies, various procaspase-8 mutants were identified in AML patients, such as Q482H and… read more here.
Keywords: q482h mutation; caspase; apoptosis; m476w q482h ... See more keywords
Integrative x-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00019
Abstract: Caspases are a critical class of proteases involved in regulating programmed cell death and other biological processes. Selective inhibitors of individual caspases, however, are lacking, due in large part to the high structural similarity found… read more here.
Keywords: integrative ray; molecular modeling; inhibitor; structure ... See more keywords
Comparing the folding landscapes of evolutionarily divergent procaspase-3
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1101/2022.01.12.476064
Abstract: All caspases evolved from a common ancestor and subsequently developed into two general classes, inflammatory or apoptotic caspases. The caspase-hemoglobinase fold has been conserved throughout nearly one billion years of evolution and is utilized for… read more here.
Keywords: comparing folding; folding landscapes; landscapes evolutionarily; folding landscape ... See more keywords
Overexpression of IRS-4 Correlates with Procaspase 3 Levels in Tumoural Tissue of Patients with Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Oncology"
DOI: 10.1155/2018/3812581
Abstract: We reported that insulin receptor substrate 4 (IRS-4) levels increased in tissue from colorectal cancer (CRC) patients and promoted retinoblastoma-cyclin-dependent kinase activation. The aim of the present study was to evaluate the effect of IRS-4… read more here.
Keywords: overexpression; tissue; cancer; tumoural tissue ... See more keywords