Microscale disruption of microorganisms for parallelized process development
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Journal"
DOI: 10.1002/biot.201600579
Abstract: Escherichia coli, Saccharomyces cerevisiae, and Pichia pastoris are the standard platforms for biopharmaceutical production with 40% of all between 2010 to 2014 approved protein drugs produced in those microbial hosts. Typically, products overexpressed E. coli… read more here.
Keywords: process development; cell disruption; disruption; microscale ... See more keywords
Rational identification of a high catalytic efficiency leucine dehydrogenase and process development for efficient synthesis of l‐phenylglycine
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology Journal"
DOI: 10.1002/biot.202200465
Abstract: Enzymatic asymmetric synthesis of chiral amino acids has great industrial potential. However, the low catalytic efficiency of high‐concentration substrates limits their industrial application. Herein, using a combination of substrate catalytic efficiency prediction based on “open… read more here.
Keywords: catalytic efficiency; process development; substrate; leucine dehydrogenase ... See more keywords
Characterisation of the E. coli HMS174 and BLR host cell proteome to guide purification process development.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology journal"
DOI: 10.1002/biot.202300068
Abstract: Mass-spectrometry-based proteomics is increasingly employed to monitor purification processes or to detect critical host cell proteins in the final drug substance. This approach is inherently unbiased and can be used to identify individual host cell… read more here.
Keywords: purification; host cell; process development;
Application of inline variable pathlength technology for rapid determination of dynamic binding capacity in downstream process development of biopharmaceuticals
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3236
Abstract: Determination of dynamic binding capacity (DBC) for capture purification chromatographic step is usually the first experiment to be performed during downstream process development of biopharmaceuticals. In this work, we investigated the application of inline variable… read more here.
Keywords: process development; pathlength technology; determination; variable pathlength ... See more keywords
Process development of [64Cu]Cu-ATSM: efficient stabilization and sterilization for therapeutic applications
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Radioanalytical and Nuclear Chemistry"
DOI: 10.1007/s10967-019-06738-9
Abstract: Hypoxia plays an important role in tumor prognosis. [64Cu]Cu-ATSM, a hypoxia-targeted radioactive agent, reportedly shows antitumor effect in vivo. For clinical application, [64Cu]Cu-ATSM must be manufactured at high concentrations to allow the administration of a… read more here.
Keywords: sterilization; 64cu atsm; atsm efficient; development 64cu ... See more keywords
Kinetic reaction modeling for antibody-drug conjugate process development.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2019.09.013
Abstract: By combining the specificity of monoclonal antibodies (mAbs) and the efficacy of cytotoxic drugs in one molecule, antibody-drug conjugates (ADCs) form a promising class of anti-cancer therapeutics. This is emphasized by around 65 molecules in… read more here.
Keywords: drug; model; reaction; process development ... See more keywords
Process development of sustainable biorefinery system integrated into the existing pulping process
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cleaner Production"
DOI: 10.1016/j.jclepro.2020.120278
Abstract: Abstract The change of paper consumption trend may jeopardize the future of pulp and paper industry. This work aims to design and develop the integrated network of biochemical and biofuel productions into existing pulp mills… read more here.
Keywords: pulping process; biorefinery integrated; process; process development ... See more keywords
Using a material property library to find surrogate materials for pharmaceutical process development
Sign Up to like & getrecommendations! Published in 2018 at "Powder Technology"
DOI: 10.1016/j.powtec.2018.08.042
Abstract: Abstract Material properties are known to have a significant impact on pharmaceutical manufacturing performance, particularly for solid product processes. Evaluating the performance of a specific material, for example an active pharmaceutical ingredient or excipient, is… read more here.
Keywords: process development; property; material property;
Process development for quantitation and vaccine efficacy assessment of recombinant hemagglutinin-neuraminidase
Sign Up to like & getrecommendations! Published in 2020 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2019.11.018
Abstract: Abstract Recombinant hemagglutinin-neuraminidase (HN) based subunit vaccine, which is non-infectious and can be produced using insect cell-culture systems, is a potential alternative to conventional live and inactivated Newcastle disease virus (NDV) vaccines. However, process development… read more here.
Keywords: process; process development; vaccine; efficacy assessment ... See more keywords
Process Development, Assessment, and Control of Reactive Dividing-Wall Column with Vapor Recompression for Producing n-Propyl Acetate
Sign Up to like & getrecommendations! Published in 2018 at "Industrial & Engineering Chemistry Research"
DOI: 10.1021/acs.iecr.8b05122
Abstract: As a combination of the conventional reactive distillation (RD) and diving-wall column, reactive diving-wall column (RDWC) is the highly thermally integrated process that has the advantages of high... read more here.
Keywords: development assessment; assessment control; column; process development ... See more keywords
Facile Process for the Development of Antiviral Cotton Fabrics with Nano-Embossed Copper Oxide
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c00492
Abstract: Metallic or metal oxide-based nanoparticles have the potential to inactivate viruses. Among various metals, copper has shown edge over others. One of the rapidly evolving areas is to combine nanoscience for production of self-sanitizing antiviral… read more here.
Keywords: copper; facile process; process development; copper oxide ... See more keywords