Process development priorities for scaling up direct microbial conversion of sugars into value‐added biochemicals
Sign Up to like & getrecommendations! Published in 2025 at "Biofuels, Bioproducts and Biorefining"
DOI: 10.1002/bbb.70095
Abstract: The study identified process development priorities toward the feasible production of five value‐added biochemicals in a sugarcane biorefinery based on achievable bioconversion performances. Multiple process scenarios using A‐molasses as feedstock were simulated in Aspen Plus®… read more here.
Keywords: process; value added; development priorities; added biochemicals ... See more keywords
Microscale disruption of microorganisms for parallelized process development
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Journal"
DOI: 10.1002/biot.201600579
Abstract: Escherichia coli, Saccharomyces cerevisiae, and Pichia pastoris are the standard platforms for biopharmaceutical production with 40% of all between 2010 to 2014 approved protein drugs produced in those microbial hosts. Typically, products overexpressed E. coli… read more here.
Keywords: process development; cell disruption; disruption; microscale ... See more keywords
Rational identification of a high catalytic efficiency leucine dehydrogenase and process development for efficient synthesis of l‐phenylglycine
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology Journal"
DOI: 10.1002/biot.202200465
Abstract: Enzymatic asymmetric synthesis of chiral amino acids has great industrial potential. However, the low catalytic efficiency of high‐concentration substrates limits their industrial application. Herein, using a combination of substrate catalytic efficiency prediction based on “open… read more here.
Keywords: catalytic efficiency; process development; substrate; leucine dehydrogenase ... See more keywords
Characterisation of the E. coli HMS174 and BLR host cell proteome to guide purification process development.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology journal"
DOI: 10.1002/biot.202300068
Abstract: Mass-spectrometry-based proteomics is increasingly employed to monitor purification processes or to detect critical host cell proteins in the final drug substance. This approach is inherently unbiased and can be used to identify individual host cell… read more here.
Keywords: purification; host cell; process development;
Application of inline variable pathlength technology for rapid determination of dynamic binding capacity in downstream process development of biopharmaceuticals
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3236
Abstract: Determination of dynamic binding capacity (DBC) for capture purification chromatographic step is usually the first experiment to be performed during downstream process development of biopharmaceuticals. In this work, we investigated the application of inline variable… read more here.
Keywords: process development; pathlength technology; determination; variable pathlength ... See more keywords
Coupling high‐throughput and modeling approaches to streamline early‐stage process development for biologics
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology Progress"
DOI: 10.1002/btpr.3523
Abstract: Platforms have long been implemented for downstream process development of monoclonal antibodies (mAbs) to streamline development and reduce timelines. These platforms are also increasingly being used for other complex biologics modalities. While development has traditionally… read more here.
Keywords: high throughput; process; process development; development ... See more keywords
Innovating cell culture process development with deep learning-powered robotic experimentation using the first Industrial Smart Lab Framework.
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology progress"
DOI: 10.1002/btpr.70051
Abstract: Traditional biologics process development, including antibody and recombinant protein production, typically relies on labor‐intensive, iterative cell culture optimization to determine optimal process parameters. To address this inefficiency, we introduced the Industrial Smart Lab Framework for… read more here.
Keywords: cell culture; process development; culture;
Small-scale fed-batch cultivations of Vibrio natriegens: overcoming challenges for early process development
Sign Up to like & getrecommendations! Published in 2025 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-025-03159-9
Abstract: Vibrio natriegens is a fast-growing microbial workhorse with high potential for biotechnological applications. However, handling the bacterium in batch processes is challenging due to its high overflow metabolism and mixed acid formation under microaerobic conditions.… read more here.
Keywords: small scale; scale fed; fed batch; early process ... See more keywords
Process development of [64Cu]Cu-ATSM: efficient stabilization and sterilization for therapeutic applications
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Radioanalytical and Nuclear Chemistry"
DOI: 10.1007/s10967-019-06738-9
Abstract: Hypoxia plays an important role in tumor prognosis. [64Cu]Cu-ATSM, a hypoxia-targeted radioactive agent, reportedly shows antitumor effect in vivo. For clinical application, [64Cu]Cu-ATSM must be manufactured at high concentrations to allow the administration of a… read more here.
Keywords: sterilization; 64cu atsm; atsm efficient; development 64cu ... See more keywords
Kinetic reaction modeling for antibody-drug conjugate process development.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2019.09.013
Abstract: By combining the specificity of monoclonal antibodies (mAbs) and the efficacy of cytotoxic drugs in one molecule, antibody-drug conjugates (ADCs) form a promising class of anti-cancer therapeutics. This is emphasized by around 65 molecules in… read more here.
Keywords: drug; model; reaction; process development ... See more keywords
Process development of sustainable biorefinery system integrated into the existing pulping process
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cleaner Production"
DOI: 10.1016/j.jclepro.2020.120278
Abstract: Abstract The change of paper consumption trend may jeopardize the future of pulp and paper industry. This work aims to design and develop the integrated network of biochemical and biofuel productions into existing pulp mills… read more here.
Keywords: pulping process; biorefinery integrated; process; process development ... See more keywords