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Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3233
Abstract: Titer improvement has driven process intensification in mAb manufacture. However, this has come with the drawback of high cell densities and associated process related impurities such as cell debris, host cell protein (HCP), and DNA.…
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Keywords:
related impurities;
x0sp;
filter;
microscopy ... See more keywords
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Published in 2020 at "European Journal of Personality"
DOI: 10.1002/per.2241
Abstract: Agreeableness is one of the major domains included within prominent hierarchical models of personality like the five–factor model. (Low) agreeableness is the strongest correlate of a variety of antisocial behaviours relative to the other five–factor…
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Keywords:
related approaches;
structural process;
personality;
process related ... See more keywords
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Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.05.012
Abstract: &NA; A specific LC‐MS method was developed for separation, identification and characterization of the process‐related substances and degradation products in tofacitinib citrate. The separation was achieved on a LiChrospher C18 column (250 mm × 4.6…
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Keywords:
degradation;
process;
related substances;
identification ... See more keywords
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Published in 2021 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2021.114001
Abstract: Empagliflozin is an effective sodium glucose cotransporter-2 (SGLT2) inhibitor to improve glycemic control in adults with type 2 diabetes. During the manufacture of empagliflozin, three unknown impurities were discovered in pilot batches ranging from 0.05…
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Keywords:
characterization novel;
isolation characterization;
novel process;
related impurities ... See more keywords
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Published in 2022 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2022.114715
Abstract: Evocalcet is a calcimimetic for the treatment of secondary hyperparathyroidism. In the preparation of evocalcet, eleven process-related impurities were detected in the reaction solution of the last step at levels of 0.05%- 2.50% by a new…
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Keywords:
identification new;
related impurities;
isolation synthesis;
synthesis identification ... See more keywords
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Published in 2020 at "Microchemical Journal"
DOI: 10.1016/j.microc.2020.104657
Abstract: Abstract Drug substances undergo degradation during manufacturing process and storage of finished pharmaceutical products which often results in the generation of degradation products. When process-related substances and degradation products are present as impurities, the therapeutic…
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Keywords:
degradation;
process;
separation;
degradation products ... See more keywords
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Published in 2018 at "Journal of Applied Physics"
DOI: 10.1063/1.5001203
Abstract: We report a systematic study of process-related electrical defects in symmetric lateral NPN transistors on silicon-on-insulator (SOI) fabricated using ion implantation for all the doped regions. A primary objective of this study is to see…
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Keywords:
electrical defects;
study process;
ion implantation;
related electrical ... See more keywords
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Published in 2021 at "Current Pharmaceutical Analysis"
DOI: 10.2174/1573412917666210604160621
Abstract: Minodronic acid (MA) is a third-generation nitrogen-containing heterocyclic bisphosphonate used to treat osteoporosis. In the process of starting materials research and preparation, the key intermediate impurities and degradation impurities have a great impact on the…
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Keywords:
impurities minodronic;
minodronic acid;
related impurities;
acid bulk ... See more keywords
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Published in 2017 at "Materials"
DOI: 10.3390/ma10020184
Abstract: In the current work, process-related thermo-mechanical changes in the rivet microstructure, joint local and global mechanical properties, and their correlation with the rivet plastic deformation regime were investigated for Ti-6Al-4V (rivet) and glass-fiber-reinforced polyester (GF-P)…
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Keywords:
friction riveted;
riveted joints;
material;
process related ... See more keywords
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Published in 2018 at "Molecules"
DOI: 10.3390/molecules23123125
Abstract: Twelve impurities (process-related and degradation) in lisdexamfetamine dimesylate (LDX), a central nervous system (CNS) stimulant drug, were first separated and quantified by high-performance liquid chromatography (HPLC) and then identified by liquid chromatography mass spectrometry (LC-MS).…
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Keywords:
related degradation;
process;
lisdexamfetamine dimesylate;
process related ... See more keywords