Analysis of fouling and breakthrough of process related impurities during depth filtration using confocal microscopy
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3233
Abstract: Titer improvement has driven process intensification in mAb manufacture. However, this has come with the drawback of high cell densities and associated process related impurities such as cell debris, host cell protein (HCP), and DNA.… read more here.
Keywords: related impurities; x0sp; filter; microscopy ... See more keywords
Merging Structural and Process–Related Approaches to the Study of Agreeableness: A Preregistered Replication and Extension Attempt
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Personality"
DOI: 10.1002/per.2241
Abstract: Agreeableness is one of the major domains included within prominent hierarchical models of personality like the five–factor model. (Low) agreeableness is the strongest correlate of a variety of antisocial behaviours relative to the other five–factor… read more here.
Keywords: related approaches; structural process; personality; process related ... See more keywords
Identification of related substances in tofacitinib citrate by LC‐MS techniques for synthetic process optimization
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.05.012
Abstract: &NA; A specific LC‐MS method was developed for separation, identification and characterization of the process‐related substances and degradation products in tofacitinib citrate. The separation was achieved on a LiChrospher C18 column (250 mm × 4.6… read more here.
Keywords: degradation; process; related substances; identification ... See more keywords
Isolation and characterization of novel process-related impurities in empagliflozin.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2021.114001
Abstract: Empagliflozin is an effective sodium glucose cotransporter-2 (SGLT2) inhibitor to improve glycemic control in adults with type 2 diabetes. During the manufacture of empagliflozin, three unknown impurities were discovered in pilot batches ranging from 0.05… read more here.
Keywords: characterization novel; isolation characterization; novel process; related impurities ... See more keywords
Isolation, synthesis, identification of new process-related impurities in evocalcet.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2022.114715
Abstract: Evocalcet is a calcimimetic for the treatment of secondary hyperparathyroidism. In the preparation of evocalcet, eleven process-related impurities were detected in the reaction solution of the last step at levels of 0.05%- 2.50% by a new… read more here.
Keywords: identification new; related impurities; isolation synthesis; synthesis identification ... See more keywords
UPLC Separation of forced degradation and process related impurities of Velpatasvir and structure elucidation by online LC-Quadrupole-Time of flight-Tandem mass Spectrometry
Sign Up to like & getrecommendations! Published in 2020 at "Microchemical Journal"
DOI: 10.1016/j.microc.2020.104657
Abstract: Abstract Drug substances undergo degradation during manufacturing process and storage of finished pharmaceutical products which often results in the generation of degradation products. When process-related substances and degradation products are present as impurities, the therapeutic… read more here.
Keywords: degradation; process; separation; degradation products ... See more keywords
Tracing Process-Related Carbon Emissions and Associated Utilizable Exhausts in China.
Sign Up to like & getrecommendations! Published in 2025 at "Environmental science & technology"
DOI: 10.1021/acs.est.5c07804
Abstract: With global efforts toward sustainable development, there has been a growing focus on the utilization of CO2-centered exhaust gases. However, the majority of the current research only considers single component and dissatisfies the requirements of… read more here.
Keywords: emissions associated; utilization; process related; carbon emissions ... See more keywords
Assessing the Manufacturability and Critical Quality Attribute Profiles of Anti-IL-8 Immunoglobulin G Mutant Variants
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.4c01010
Abstract: Early-phase manufacturability assessment of high-concentration therapeutic monoclonal antibodies (mAbs) involves screening of process-related risks impacting their translation into the clinic. Manufacturing a mAb at scale relies on cost-effective and robust approaches to derisk manufacturability parameters,… read more here.
Keywords: manufacturability critical; quality attribute; assessing manufacturability; manufacturability ... See more keywords
A study of process-related electrical defects in SOI lateral bipolar transistors fabricated by ion implantation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Physics"
DOI: 10.1063/1.5001203
Abstract: We report a systematic study of process-related electrical defects in symmetric lateral NPN transistors on silicon-on-insulator (SOI) fabricated using ion implantation for all the doped regions. A primary objective of this study is to see… read more here.
Keywords: electrical defects; study process; ion implantation; related electrical ... See more keywords
Integrating single-cell and bulk RNA sequencing data unveils antigen presentation and process-related CAFS and establishes a predictive signature in prostate cancer
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-023-04807-y
Abstract: Cancer-associated fibroblasts (CAFs) are heterogeneous and can influence the progression of prostate cancer in multiple ways; however, their capacity to present and process antigens in PRAD has not been investigated. In this study, antigen presentation… read more here.
Keywords: process; antigen presentation; process related; cafs ... See more keywords
Identification, characterization, and determination of process-related impurities in Minodronic Acid bulk drug
Sign Up to like & getrecommendations! Published in 2021 at "Current Pharmaceutical Analysis"
DOI: 10.2174/1573412917666210604160621
Abstract: Minodronic acid (MA) is a third-generation nitrogen-containing heterocyclic bisphosphonate used to treat osteoporosis. In the process of starting materials research and preparation, the key intermediate impurities and degradation impurities have a great impact on the… read more here.
Keywords: impurities minodronic; minodronic acid; related impurities; acid bulk ... See more keywords