Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy
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DOI: 10.1016/j.cell.2018.09.027
Abstract: The super elongation complex (SEC) is required for robust and productive transcription through release of RNA polymerase II (Pol II) with its P-TEFb module and promoting transcriptional processivity with its ELL2 subunit. Malfunction of SEC… read more here.
Keywords: cancer; processive transcription; transcription elongation; sec ... See more keywords