Kinesin Processivity Is Determined by a Kinetic Race from a Vulnerable One-Head-Bound State.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.05.007
Abstract: Kinesin processivity, defined as the average number of steps that occur per interaction with a microtubule, is an important biophysical determinant of the motor's intracellular capabilities. Despite its fundamental importance to the diversity of tasks… read more here.
Keywords: head; kinesin processivity; state; one head ... See more keywords
Engineering Transcriptional Interference through RNA Polymerase Processivity Control.
Sign Up to like & getrecommendations! Published in 2021 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.0c00534
Abstract: Antisense transcription is widespread in all kingdoms of life and has been shown to influence gene expression through transcriptional interference (TI), a phenomenon in which one transcriptional process negatively influences another in cis. The processivity,… read more here.
Keywords: transcriptional interference; biology; processivity; processivity control ... See more keywords
Limited processivity of single motors improves overall transport flux of self-assembled motor-cargo complexes.
Sign Up to like & getrecommendations! Published in 2019 at "Physical review. E"
DOI: 10.1103/physreve.100.022408
Abstract: Single kinesin molecular motors can processively move along a microtubule (MT) a few micrometers on average before dissociating. However, cellular length scales over which transport occurs are several hundred microns and more. Why seemingly unreliable… read more here.
Keywords: transport; cargo; processivity; motor ... See more keywords
GGCX mutants that impair hemostasis reveal the importance of processivity and full carboxylation to VKD protein function.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021014275
Abstract: The gamma-glutamyl carboxylase (GGCX) generates multiple carboxylated Glus (Glas) in vitamin K-dependent (VKD) proteins that are required for their functions. GGCX is processive, remaining bound to VKD proteins throughout the multiple Glu carboxylations, and this… read more here.
Keywords: vkd protein; vkd; carboxylation; processivity ... See more keywords
The Arabidopsis kinesin-4, FRA1, requires a high level of processive motility to function correctly
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.196857
Abstract: ABSTRACT Processivity is important for kinesins that mediate intracellular transport. Structure–function analyses of N-terminal kinesins (i.e. kinesins comprising their motor domains at the N-terminus) have identified several non-motor regions that affect processivity in vitro. However,… read more here.
Keywords: processive motility; processivity; function; kinesin ... See more keywords