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Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202024
Abstract: Although having undergone decades of development, nanoparticulate drug delivery vehicles for efficient cancer therapy remain a challenge, confined by low drug loading, instability, and poor cancer tissue selectivity. A self‐assembled prodrug, the combination of prodrug…
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Keywords:
therapy;
prodrug;
cancer therapy;
porphyrin centered ... See more keywords
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Published in 2018 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201700256
Abstract: Oxaprozin is a popular non‐steroidal anti‐inflammatory drug (NSAID) and its chronic oral use is clinically restricted due to its gastrointestinal (GI) complications. In order to circumvent the GI complications, oxaprozin was amended as a prodrug…
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Keywords:
anti inflammatory;
prodrug safer;
inflammatory drug;
prodrug ... See more keywords
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Published in 2017 at "Journal of Materials Science"
DOI: 10.1007/s10853-017-1546-z
Abstract: Stimuli-responsive nanomedicine shows high therapeutic effects and low side effects to tumor cells and tissues, representing a preferable therapeutics for cancer therapy. Herein, we design an acid-stimuli-responsive doxorubicin polymeric prodrug (OM@DOX), and this amphiphilic prodrug…
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Keywords:
tumor cells;
drug;
prodrug;
high drug ... See more keywords
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Published in 2019 at "Pharmaceutical Research"
DOI: 10.1007/s11095-019-2587-6
Abstract: BackgroundTofacitinib (Tofa) has been approved for moderately to severely active ulcerative colitis (UC). To improve its therapeutic efficacy and limit dose-dependent toxicity, we developed a macromolecular prodrug of Tofa (P-Tofa). If the prodrug design improves…
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Keywords:
tofa;
prodrug;
ulcerative colitis;
mice ... See more keywords
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Published in 2020 at "Acta tropica"
DOI: 10.1016/j.actatropica.2020.105411
Abstract: Alveolar echinococcosis is one of the most dangerous parasitic zoonoses. This disease, widely distributed in the northern hemisphere, is caused by the metacestode stage of the tapeworm Echinococcus multilocularis. All surgical and non-surgical patients should…
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Keywords:
menthol pentanol;
echinococcus multilocularis;
prodrug;
menthol ... See more keywords
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Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.01.014
Abstract: Polymeric prodrugs are of immense interest as anticancer drug-delivery system owing to their superior drug stability during circulation and satisfactory drug loading capacity. However, they are usually less effective than free drugs due to imperfect…
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Keywords:
sensibilization effect;
delivery;
drug;
prodrug ... See more keywords
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Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.07.014
Abstract: The goal of nanomedicine is to seek strategies that are more efficient to address various limitations and challenges faced by conventional medicines, including lack of target specificity, poor bioavailability, premature degradability, and undesired side effects.…
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Keywords:
tumor cells;
drug;
prodrug;
prodrug amphiphiles ... See more keywords
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Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.10.023
Abstract: Long-acting parenteral (LAP) antiretroviral drugs have generated considerable interest for treatment and prevention of HIV-1 infection. One new LAP is cabotegravir (CAB), a highly potent integrase inhibitor, with a half-life of up to 54 days,…
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Keywords:
creation nanoformulated;
prodrug improved;
nanoformulated cabotegravir;
cab ... See more keywords
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Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.12.002
Abstract: The effective design of a targeted drug delivery system could improve the therapeutic efficacy of anticancer drugs by reducing their undesirable adsorption and toxic side effects. Here, an RGD-peptide functionalized and bioresponsive ruthenium prodrug (Ru-RGD)…
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Keywords:
clinical diagnosis;
therapy;
prodrug;
cancer ... See more keywords
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Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120823
Abstract: Bioorthogonal prodrug activation is fascinating but suffers from staggered administration of prodrug and trigger, which would not only reduce the therapeutic effect but bring great inconvenience for clinical application. Herein, we report a new cross-linked…
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Keywords:
bioorthogonal prodrug;
prodrug activation;
prodrug;
one stitch ... See more keywords
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Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.121258
Abstract: Current therapy in acute myeloid leukemia (AML) is based on chemotherapeutic drugs administered at high doses, lacking targeting selectivity and displaying poor therapeutic index because of severe adverse effects. Here, we develop a novel nanoconjugate…
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Keywords:
ara prodrug;
prodrug;
acute myeloid;
myeloid leukemia ... See more keywords