Flucytosine‐based prodrug activation by cold physical plasma
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200061
Abstract: Reactive oxygen species (ROS) are known to trigger drug release from arylboronate‐containing ROS‐responsive prodrugs. In cancer cells, elevated levels of ROS can be exploited for the selective activation of prodrugs via Baeyer–Villiger type oxidation rearrangement… read more here.
Keywords: physical plasma; cold physical; flucytosine based; prodrug activation ... See more keywords
"One-stitch" bioorthogonal prodrug activation based on cross-linked lipoic acid nanocapsules.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120823
Abstract: Bioorthogonal prodrug activation is fascinating but suffers from staggered administration of prodrug and trigger, which would not only reduce the therapeutic effect but bring great inconvenience for clinical application. Herein, we report a new cross-linked… read more here.
Keywords: bioorthogonal prodrug; prodrug activation; prodrug; one stitch ... See more keywords
Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00632
Abstract: Structure-property relationships associated with a series of (carbonyl)oxyalkyl amino acid ester prodrugs of the marketed HIV-1 protease inhibitor atazanavir (1), designed to enhance the systemic drug delivery, were examined. Compared to previously reported prodrugs, optimized… read more here.
Keywords: carbonyl oxyalkyl; prodrug activation; cmax; drug delivery ... See more keywords
Radiotherapy Reduces N-Oxides for Prodrug Activation in Tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c02521
Abstract: Precisely activating chemotherapeutic prodrugs in a tumor-selective manner is an ideal way to cure cancers without causing systemic toxicities. Although many efforts have been made, developing spatiotemporally controllable activation methods is still an unmet challenge.… read more here.
Keywords: radiotherapy reduces; oxides prodrug; prodrug activation; activation ... See more keywords
Intracellular fluorogenic supramolecular assemblies for self-reporting bioorthogonal prodrug activation.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00972b
Abstract: A visual drug delivery system (DDS) is urgently needed for precision medicine. DDS-mediated bioorthogonal prodrug activation strategies have demonstrated remarkable advantages in enlarging a therapeutic index via the alleviation of adverse drug reactions. However, the… read more here.
Keywords: supramolecular assemblies; self reporting; prodrug activation; bioorthogonal prodrug ... See more keywords
Abstract LB-B23: Prodrug activation by designer enzyme targeted to CD123-expressing tumors
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-lb-b23
Abstract: We propose the combination of tumor-targeting antibodies with a drug-activating enzyme and a prodrug, which could be expected to give synergy and enhanced therapeutic efficacy in the treatment of leukemia and other malignancies. We have… read more here.
Keywords: designer; prodrug activation; enzyme targeted; designer enzyme ... See more keywords
Nitroreductase-induced bioorthogonal ligation for prodrug activation: A traceless strategy for cancer-specific imaging and therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.2139/ssrn.4156111
Abstract: Prodrug development is of great interest in cancer therapy. From bio-friendly standpoints, traceless prodrug activation would be an ideal approach for cancer treatment owning to the avoidance of byproduct which might induce side effects in… read more here.
Keywords: traceless strategy; strategy cancer; prodrug activation; therapy ... See more keywords