Acid-activatable doxorubicin prodrug micelles with folate-targeted and ultra-high drug loading features for efficient antitumor drug delivery
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Materials Science"
DOI: 10.1007/s10853-017-1546-z
Abstract: Stimuli-responsive nanomedicine shows high therapeutic effects and low side effects to tumor cells and tissues, representing a preferable therapeutics for cancer therapy. Herein, we design an acid-stimuli-responsive doxorubicin polymeric prodrug (OM@DOX), and this amphiphilic prodrug… read more here.
Keywords: tumor cells; drug; prodrug; high drug ... See more keywords
Intelligent self-assembly prodrug micelles loading doxorubicin in response to tumor microenvironment for targeted tumors therapy
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Journal of Chemical Engineering"
DOI: 10.1016/j.cjche.2021.06.023
Abstract: Abstract Compared with physical drug-loaded nanocarriers, polymeric prodrug micelles have many advantages such as high drug loading and enhanced stability in blood, so they have great potential in cancer therapy. However, these micelles have a… read more here.
Keywords: response; drug; self; tumor microenvironment ... See more keywords
Increased the TMZ concentration in brain by poly(2-ethyl-2-oxazoline) conjugated temozolomide prodrug micelles for glioblastoma treatment
Sign Up to like & getrecommendations! Published in 2021 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2020.110232
Abstract: Abstract The current treatment of glioblastoma (GBM) remains challenging. Temozolomide (TMZ), a first-line chemotherapy drug used to treat glioblastoma, is rapidly cleared under normal physiological conditions and has poor stability, which severely limits its efficacy.… read more here.
Keywords: increased tmz; ethyl oxazoline; treatment; tmz ... See more keywords
One-Pot Synthesis of pH/Redox Responsive Polymeric Prodrug and Fabrication of Shell Cross-Linked Prodrug Micelles for Antitumor Drug Transportation.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00421
Abstract: Shell cross-linked (SCL) polymeric prodrug micelles have the advantages of good blood circulation stability and high drug content. Herein, we report on a new kind of pH/redox responsive dynamic covalent SCL micelle, which was fabricated… read more here.
Keywords: shell cross; cross linked; polymeric prodrug; prodrug ... See more keywords