Tuning the efficacy of esterase-activatable prodrug nanoparticles for the treatment of colorectal malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120705
Abstract: Colorectal cancer (CRC) is one of the most common and lethal human cancers, and the clinical outcomes remain unsatisfactory because of the lack of effective and safe therapeutic regimens. Here, we describe a practical and… read more here.
Keywords: sn38; efficacy; esterase activatable; esterase ... See more keywords
Enzyme/pH dual-responsive polymer prodrug nanoparticles based on 10-hydroxycamptothecin-carboxymethylchitosan for enhanced drug stability and anticancer efficacy
Sign Up to like & getrecommendations! Published in 2019 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2019.04.050
Abstract: Abstract For enhanced stability and anticancer efficacy, the 10-Hydroxycamptothecin (10-HCPT) structure based pH/enzyme responsive polymeric prodrug nanoparticles were constructed by conjugating 10-HCPT to carboxymethylchitosan (CMCS) via pH/enzyme sensitive succinyl linkage followed by ultrasonic dispersion. At… read more here.
Keywords: drug; anticancer efficacy; prodrug nanoparticles; stability anticancer ... See more keywords
Gemcitabine lipid prodrug nanoparticles: switching the lipid moiety and changing the fate in the bloodstream.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.121076
Abstract: A simple approach to achieve a lipoprotein (LP)-mediated drug delivery consists to trigger the spontaneous drug insertion into endogenous lipoproteins in the bloodstream, by means of its chemical modification. Nanoparticles (NPs) made of the squalene-gemcitabine… read more here.
Keywords: gemcitabine; drug; bloodstream; moiety ... See more keywords
Zwitterionic stealth peptide-capped 5-aminolevulinic acid prodrug nanoparticles for targeted photodynamic therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2016.09.012
Abstract: 5-Aminolevulinic acid (ALA) is a FDA-approved photodynamic therapy (PDT) precursor of protoporphyrin IX (PpIX) used for treating various cancers. However, the internalization of ALA is a big challenge due to its hydrophilic nature and low… read more here.
Keywords: stealth peptide; aminolevulinic acid; prodrug nanoparticles;
Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c19058
Abstract: Responsive drug delivery systems possess great potential in disease diagnosis and treatment. Herein, we develop an activatable prodrug and fluorescence imaging material by engineering the endogenous NAD(P)H:quinone oxidoreductase-1 (NQO1) responsive linker. The as-prepared nanomaterials possess… read more here.
Keywords: prodrug; chemotherapy; enzyme responsive; tumor specific ... See more keywords
Fluorescent polymer prodrug nanoparticles with aggregation-induced emission (AIE) properties from nitroxide-mediated polymerization.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc09052d
Abstract: Aggregation-induced emission (AIE)-active polymer prodrug nanoparticles were readily prepared by growing short, well-defined polymer chains from an AIE dye by nitroxide-mediated polymerization, followed by co-nanoprecipitation of the resulting conjugates with similarly constructed anticancer polymer prodrugs.… read more here.
Keywords: polymer prodrug; aggregation induced; polymer; emission aie ... See more keywords
Enhanced oral bioavailability of self-assembling curcumin–vitamin E prodrug-nanoparticles by co-nanoprecipitation with vitamin E TPGS
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2020.1821049
Abstract: Abstract Curcumin (CUR), a nontoxic natural compound with potent antitumor activity, was limited in clinical application due to its insolubility and exceedingly low bioavailability. In this study, a novel prodrug-nanoparticle (CSSV/TPGS-NPs) self-assembled by co-nanoprecipitation of… read more here.
Keywords: tpgs nps; cssv tpgs; bioavailability; vitamin tpgs ... See more keywords
CD163 Monoclonal Antibody Modified Polymer Prodrug Nanoparticles for Targeting Tumor-Associated Macrophages (TAMs) to Enhance Anti-Tumor Effects
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041241
Abstract: Tumor-associated macrophages (TAMs)-based immunotherapy is a promising strategy. Since TAMs are mainly composed of M2-type macrophages, they have a promoting effect on tumor growth, invasion, and metastasis. M2-type macrophages contain a specific receptor CD163 on… read more here.
Keywords: monoclonal antibody; cd163 monoclonal; prodrug nanoparticles; polymer prodrug ... See more keywords