Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1173432
Abstract: Gastrointestinal malignancies are common digestive system tumor worldwide. Nucleoside analogues have been widely used as anticancer drugs for the treatment of a variety of conditions, including gastrointestinal malignancies. However, low permeability, enzymatic deamination, inefficiently phosphorylation,… read more here.
Keywords: nucleoside analogues; strategies nucleoside; treatment gastrointestinal; prodrug strategies ... See more keywords
Expanding the toolbox of metabolically stable lipid prodrug strategies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1083284
Abstract: Nucleoside- and nucleotide-based therapeutics are indispensable treatment options for patients suffering from malignant and viral diseases. These agents are most commonly administered to patients as prodrugs to maximize bioavailability and efficacy. While the literature provides… read more here.
Keywords: toolbox metabolically; expanding toolbox; metabolically stable; prodrug ... See more keywords