Inhibitory Effects on RNA Binding and RNase H Induction Activity of Prodrug-Type Oligodeoxynucleotides Modified with a Galactosylated Self-Immolative Linker Cleavable by β-Galactosidase.
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DOI: 10.1021/acs.bioconjchem.4c00376
Abstract: Prodrug-type oligonucleotides (prodrug-ONs) are a class of oligonucleotide designed for activation under specific intracellular conditions or external stimuli. Prodrug-ONs can be activated in the target tissues or cells, thereby reducing the risk of adverse effects.… read more here.
Keywords: self immolative; prodrug type; linker; type oligodeoxynucleotides ... See more keywords