Colchicine prodrugs and codrugs: Chemistry and bioactivities.
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DOI: 10.1016/j.ejmech.2017.12.029
Abstract: Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-target cell. However, diverse colchicine analogs have been derivatized as intentions for toxicity reduction and structure-activity relationship (SAR) studying. Hybrid system of colchicine… read more here.
Keywords: chemistry; colchicine prodrugs; colchicine; chemistry bioactivities ... See more keywords
Mutual Prodrugs - Codrugs.
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DOI: 10.2174/0929867330666221209102650
Abstract: This review encapsulates an extensive variety of substances identified as mutual prodrugs or codrugs, wherein two, or sometimes three, biologically active moieties are linked using an assortment of metabolically unstable bridging entities. Following the administration… read more here.
Keywords: chemistry; prodrugs codrugs; mutual prodrugs;