In Situ Metabolomics of Cortisol-Producing Adenomas.
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DOI: 10.1093/clinchem/hvac191
Abstract: BACKGROUND Recent advances in omics techniques have allowed detailed genetic characterization of cortisol-producing adrenal adenoma (CPA). In contrast, the pathophysiology of CPAs has not been elucidated in detail on the level of tumor metabolic alterations.… read more here.
Keywords: adenomas; cortisol producing; situ metabolomics; metabolomics cortisol ... See more keywords
Aldosterone-Producing Adenomas: Genotypes and Phenotypes.
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DOI: 10.1161/hypertensionaha.117.09161
Abstract: See related article, pp 129–136 Primary aldosteronism (PA), which can be detected by aldosterone-to-renin ratio in its great majority, has come to be conceived as the most frequent form of secondary hypertension constituting ≈5% to… read more here.
Keywords: aldosterone producing; hypertension; adenomas genotypes; producing adenomas ... See more keywords
TSPAN12 (Tetraspanin 12) Is a Novel Negative Regulator of Aldosterone Production in Adrenal Physiology and Aldosterone-Producing Adenomas
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DOI: 10.1161/hypertensionaha.122.19783
Abstract: Background: Aldosterone-producing adenomas (APAs) are a major cause of primary aldosteronism, a condition of low-renin hypertension, in which aldosterone overproduction is usually driven by a somatic activating mutation in an ion pump or channel. TSPAN12… read more here.
Keywords: tspan12 tetraspanin; aldosterone producing; physiology; producing adenomas ... See more keywords
Activating PRKACB somatic mutation in cortisol-producing adenomas.
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DOI: 10.1172/jci.insight.98296
Abstract: Mutations in the gene encoding the protein kinase A (PKA) catalytic subunit α have been found to be responsible for cortisol-producing adenomas (CPAs). In this study, we identified by whole-exome sequencing the somatic mutation p.S54L… read more here.
Keywords: cortisol producing; somatic mutation; pka; producing adenomas ... See more keywords
Age-Dependent Progression of Renal Dysfunction After Adrenalectomy for Aldosterone-Producing Adenomas in Japan
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DOI: 10.1210/js.2018-00260
Abstract: Abstract Context In patients with aldosterone-producing adenomas (APAs), adrenalectomy causes a rapid decrease in blood pressure and increase in blood potassium levels; however, the effects of these intensive metabolic changes on kidney function with age… read more here.
Keywords: age; aldosterone producing; producing adenomas; progression ... See more keywords