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   Articles with "producing adenomas" as a keyword



Myosteatosis and sarcopenia are linked to autonomous cortisol secretion in patients with aldosterone-producing adenomas

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recommendations! Published in 2024 at "Hypertension Research"

DOI: 10.1038/s41440-024-01933-y

Abstract: Patients with adrenal aldosterone-producing adenomas (APA) face elevated cardiovascular risks, especially when cortisol is co-secreted, yet the impact on muscle health remains unclear. Myosteatosis, characterized by fatty infiltration into muscles, is linked to cardiometabolic diseases… read more here.

Keywords: autonomous cortisol; area; muscle; aldosterone producing ... See more keywords

In Situ Metabolomics of Cortisol-Producing Adenomas.

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recommendations! Published in 2022 at "Clinical chemistry"

DOI: 10.1093/clinchem/hvac191

Abstract: BACKGROUND Recent advances in omics techniques have allowed detailed genetic characterization of cortisol-producing adrenal adenoma (CPA). In contrast, the pathophysiology of CPAs has not been elucidated in detail on the level of tumor metabolic alterations.… read more here.

Keywords: adenomas; cortisol producing; situ metabolomics; metabolomics cortisol ... See more keywords

Adipose Tissue Signaling in Aldosterone-Producing Adenomas: Paracrine and Endocrine Effects.

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recommendations! Published in 2025 at "European journal of endocrinology"

DOI: 10.1093/ejendo/lvaf190

Abstract: BACKGROUND Primary aldosteronism increases the risk of cardiovascular and metabolic diseases, which might be influenced by different adipose tissue compartments. However, the interaction between the adrenal gland and different fat depots is not well understood… read more here.

Keywords: paat; scat; aldosterone producing; producing adenomas ... See more keywords

Aldosterone-Producing Adenomas: Genotypes and Phenotypes.

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recommendations! Published in 2017 at "Hypertension"

DOI: 10.1161/hypertensionaha.117.09161

Abstract: See related article, pp 129–136 Primary aldosteronism (PA), which can be detected by aldosterone-to-renin ratio in its great majority, has come to be conceived as the most frequent form of secondary hypertension constituting ≈5% to… read more here.

Keywords: aldosterone producing; hypertension; adenomas genotypes; producing adenomas ... See more keywords

TSPAN12 (Tetraspanin 12) Is a Novel Negative Regulator of Aldosterone Production in Adrenal Physiology and Aldosterone-Producing Adenomas

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recommendations! Published in 2022 at "Hypertension"

DOI: 10.1161/hypertensionaha.122.19783

Abstract: Background: Aldosterone-producing adenomas (APAs) are a major cause of primary aldosteronism, a condition of low-renin hypertension, in which aldosterone overproduction is usually driven by a somatic activating mutation in an ion pump or channel. TSPAN12… read more here.

Keywords: tspan12 tetraspanin; aldosterone producing; physiology; producing adenomas ... See more keywords

Somatic Mutations in MCOLN3 Are Associated With Aldosterone-Producing Adenomas.

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recommendations! Published in 2025 at "Hypertension"

DOI: 10.1161/hypertensionaha.125.24909

Abstract: BACKGROUND Primary aldosteronism is a common but underdiagnosed cause of endocrine hypertension that contributes to global cardiovascular morbidity and mortality. It is characterized by renin-independent hyperaldosteronism that originates from adrenal lesions-the majority of which are… read more here.

Keywords: aldosterone; somatic mutations; aldosterone producing; primary aldosteronism ... See more keywords

Activating PRKACB somatic mutation in cortisol-producing adenomas.

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recommendations! Published in 2018 at "JCI insight"

DOI: 10.1172/jci.insight.98296

Abstract: Mutations in the gene encoding the protein kinase A (PKA) catalytic subunit α have been found to be responsible for cortisol-producing adenomas (CPAs). In this study, we identified by whole-exome sequencing the somatic mutation p.S54L… read more here.

Keywords: cortisol producing; somatic mutation; pka; producing adenomas ... See more keywords

Age-Dependent Progression of Renal Dysfunction After Adrenalectomy for Aldosterone-Producing Adenomas in Japan

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recommendations! Published in 2019 at "Journal of the Endocrine Society"

DOI: 10.1210/js.2018-00260

Abstract: Abstract Context In patients with aldosterone-producing adenomas (APAs), adrenalectomy causes a rapid decrease in blood pressure and increase in blood potassium levels; however, the effects of these intensive metabolic changes on kidney function with age… read more here.

Keywords: age; aldosterone producing; producing adenomas; progression ... See more keywords