Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation
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DOI: 10.1038/s41423-024-01233-y
Abstract: Germinal centers where B cells undergo clonal expansion and antibody affinity maturation are hypoxic microenvironments. However, the function of hypoxia-inducible factor (HIF)-1α in immunoglobulin production remains incompletely characterized. Here, we demonstrated that B cells lacking… read more here.
Keywords: cell differentiation; intestinal inflammation; producing cell; iga producing ... See more keywords
Aldosterone-Producing Cell Clusters Frequently Harbor Somatic Mutations and Accumulate With Age in Normal Adrenals
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DOI: 10.1210/js.2017-00134
Abstract: Context: Aldosterone synthase (CYP11B2) immunohistochemistry and next-generation sequencing (NGS) have revealed the frequent presence of aldosterone-producing cell clusters (APCCs) harboring somatic mutations in aldosterone-regulating genes in adrenals from Americans without defined hypertension status. Objective: Determine… read more here.
Keywords: cell clusters; age; somatic mutations; producing cell ... See more keywords
Impact of aldosterone-producing cell clusters on diagnostic discrepancies in primary aldosteronism
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DOI: 10.18632/oncotarget.25418
Abstract: Adrenocorticotropic hormone (ACTH) stimulation is recommended in adrenal vein sampling (AVS) for primary aldosteronism (PA) to improve the AVS success rate. However, this method can confound the subtype diagnosis. Gene mutations or pathological characteristics may… read more here.
Keywords: post acth; primary aldosteronism; diagnostic discrepancies; producing cell ... See more keywords
Steroidogenic differentiation of human amniotic membrane-derived mesenchymal stem cells into a progesterone-/androgen-producing cell lineage by SF-1 and an estrogen-producing cell lineage by WT1−KTS
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2024.1410433
Abstract: Background Sex steroid hormones, primarily synthesized by gonadal somatic cells, are pivotal for sexual development and reproduction. Mice studies have shown that two transcription factors, steroidogenic factor 1 (SF-1) and Wilms’ tumor 1 (WT1), are… read more here.
Keywords: differentiation; producing cell; cell; cell lineage ... See more keywords