Predictive value of surveillance cultures for bacteremia caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales among patients with hematological diseases
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DOI: 10.1007/s15010-021-01753-z
Abstract: Due to the increasing prevalence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales, empirical therapies with cefepime or piperacillin/tazobactam for hematology patients with febrile neutropenia have become ineffective. Carbapenems should be administered as soon as possible in such… read more here.
Keywords: surveillance; culture; hematology; producing enterobacterales ... See more keywords
H2dpa derivatives containing pentadentate ligands: An acyclic adjuvant potentiates meropenem activity in vitro and in vivo against metallo-β-lactamase-producing Enterobacterales.
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DOI: 10.1016/j.ejmech.2021.113702
Abstract: The emergence and dissemination of metallo-β-lactamases (MBLs) producing Enterobacterales is a great concern for public health due to the limited therapeutic options. No MBL inhibitors are currently available in clinical practice. Herein, we synthesized a… read more here.
Keywords: containing pentadentate; derivatives containing; h2dpa derivatives; producing enterobacterales ... See more keywords
Occurrence of CTX-M-15 and MCR-1-producing Enterobacterales in pigs, Portugal; evidences of direct links with antibiotic selective pressure.
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DOI: 10.1016/j.ijantimicag.2019.09.006
Abstract: BACKGROUND Our study aimed to prospectively analyze the occurrence of colistin-resistant and extended-spectrum ß-lactamase (ESBL)-producing Enterobacterales colonizing pigs in two farms in Portugal, and to evaluate the putative correlations with different antibiotic usages. MATERIAL AND… read more here.
Keywords: antibiotic selective; colistin; occurrence; producing enterobacterales ... See more keywords
Carbapenemases detection testing in the era of ceftazidime-avibactam resistant KPC-producing Enterobacterales: a two-year experience.
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DOI: 10.1016/j.jgar.2021.02.008
Abstract: OBJECTIVE This study aims to investigate the prevalence of ceftazidime-avibactam (CZA) resistance among carbapenemase-producing Enterobacterales (CPE) blood culture (BC) isolates and the performance of the main carbapenemase phenotypic detection methods to identify KPC variants associated… read more here.
Keywords: ceftazidime avibactam; carbapenemase; resistance; producing enterobacterales ... See more keywords
Genomic characterization of three GES-producing Enterobacterales isolated in the Czech Republic.
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DOI: 10.1016/j.jgar.2022.02.016
Abstract: BACKGROUND The aim of the study is to characterize the genomic features of three GES-producing Enterobacterales isolates from Czech Hospitals. METHODS In 2020, during a routine screening of the hospital's surfaces in Prague General Hospital,… read more here.
Keywords: genomic characterization; ges producing; characterization three; three ges ... See more keywords
Epidemiology of carbapenemase-producing Enterobacterales in the Middle East: a systematic review
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DOI: 10.1080/14787210.2020.1729126
Abstract: ABSTRACT Introduction The Middle East is actually recognized as endemic for carbapenemases-producing Enterobacterales (CPE) including at least OXA-48-like and NDM-like. Areas covered We performed a search of PubMed and Scopus using relevant keywords. We included… read more here.
Keywords: carbapenemase producing; middle east; epidemiology; producing enterobacterales ... See more keywords
Efficacy of Noncarbapenem β-Lactams Compared to Carbapenems for Extended-Spectrum β-Lactamase–Producing Enterobacterales Urinary Tract Infections
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DOI: 10.1093/ofid/ofac034
Abstract: Abstract Background Extended-spectrum β-lactamase (ESBL)–producing Enterobacterales are frequent causes of urinary tract infections (UTIs). Severe infections caused by ESBL Enterobacterales are often treated with carbapenems, but optimal treatment for less severe infections such as UTIs… read more here.
Keywords: extended spectrum; urinary tract; producing enterobacterales; tract infections ... See more keywords
Dissemination of carbapenemase-producing Enterobacterales in Ireland from 2012 to 2017: a retrospective genomic surveillance study
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DOI: 10.1099/mgen.0.000924
Abstract: The spread of carbapenemase-producing Enterobacterales (CPE) is of major public health concern. The transmission dynamics of CPE in hospitals, particularly at the national level, are not well understood. Here, we describe a retrospective nationwide genomic… read more here.
Keywords: carbapenemase producing; producing enterobacterales; genomic surveillance; 2012 2017 ... See more keywords
Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase‐producing Enterobacterales: The impact of cytomegalovirus disease and lymphopenia
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DOI: 10.1111/ajt.15769
Abstract: Treatment of carbapenemase‐producing Enterobacterales bloodstream infections in solid organ transplant recipients is challenging. The objective of this study was to develop a specific score to predict mortality in solid organ transplant recipients with carbapenemase‐producing Enterobacterales… read more here.
Keywords: carbapenemase producing; organ transplant; solid organ; mortality ... See more keywords
Thirty-Day Mortality Rates in Patients with Extended-Spectrum β-Lactamase-Producing Enterobacterales Bacteremia Receiving Ertapenem versus Other Carbapenems
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DOI: 10.1128/aac.00287-22
Abstract: Ertapenem is one of the carbapenems recommended for treating extended-spectrum β-lactamase (ESBL)-producing Enterobacterales. However, efficacy data are limited. ABSTRACT Ertapenem is one of the carbapenems recommended for treating extended-spectrum β-lactamase (ESBL)-producing Enterobacterales. However, efficacy data… read more here.
Keywords: day; mortality rates; producing enterobacterales; spectrum lactamase ... See more keywords
Aztreonam-Avibactam Susceptibility Testing Program for Metallo-Beta-Lactamase-Producing Enterobacterales in the Antibiotic Resistance Laboratory Network, March 2019 to December 2020
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DOI: 10.1128/aac.00486-21
Abstract: Aztreonam-avibactam is a drug combination pending phase 3 clinical trials and is suggested for treatment of severe infections caused by metallo-beta-lactamase (MBL)-producing Enterobacterales by combining ceftazidime-avibactam and aztreonam. Beginning in 2019, four Antibiotic Resistance Laboratory… read more here.
Keywords: producing enterobacterales; metallo beta; aztreonam avibactam; resistance laboratory ... See more keywords